ABCB1(redirected from P-glycoprotein 1)
ABCB1A gene on chromosome 7p21.12, which encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane protein. It is an ATP-dependent efflux pump for xenobiotics with broad substrate specificity, and functions as a transporter in the blood-brain barrier.
The ABCB1 protein product is responsible for reducing drug loads in multi-drug-resistant cells, thereby mediating resistance to anti-cancer drugs.
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ABCB1Member 1 of the B subfamily of ABC TRANSPORTER PROTEINS. Also known as MDR1. Polymorphism of the gene for ABCB1 is associated with multi-drug resistance in the treatment of a range of diseases including epilepsy, various cancers, rheumatoid arthritis and inflammatory bowel disease. Clinical experience has shown that several drugs used to treat cancer may become ineffective simultaneously in spite of having unrelated chemical structure. This multi-drug resistance was shown to be due to enhanced expression of ABCB1 which was using ATP-derived energy to export drugs from the cytosol to the extracellular fluid.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005