P-glycoprotein


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Related to P-glycoprotein: ABCB1

glycoprotein

 [gli″ko-pro´tēn]
any of a class of conjugated proteins consisting of a compound of protein with a carbohydrate group.
α1-acid glycoprotein an acute phase protein found in blood plasma, an indicator of tissue necrosis and inflammation. Called also orosomucoid.
P-glycoprotein a cell-surface protein occurring normally in the colon, small intestine, adrenal glands, kidney, and liver, and also expressed by tumor cells. It is a modulator of multidrug resistance, mediating the transport of antineoplastic agents out of tumor cells.
variable surface glycoprotein any of several glycoproteins that form the antigenic protein coating of Trypanosoma brucei. The organisms contain numerous genes encoding hundreds of such glycoproteins and, by expressing individual ones successively, evade the immune system of the host.

P-gly·co·pro·tein

(glī'kō-prō'tēn),
Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.
Synonym(s): P-170

P-gly·co·pro·tein

(glī'kō-prō'tēn)
Protein associated with tumor multidrug resistance; acts as an energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

P-glycoprotein

A cell membrane pump that influences cellular uptake and release of chemicals. It affects the relative resistance or susceptibility of cells to drug therapy.
See also: glycoprotein
References in periodicals archive ?
Pharmacokinetic interaction of cytochrome p450 3A-related compounds with rhodamine 123, a p-glycoprotein substrate, in rats pretreated with dexamethasone.
NIEHS postbaccalaureate fellow David Banks is lead author on the paper and described amitriptylines action on P-glycoprotein as rapid and reversible.
pylori induces P-glycoprotein expression in the human gastrointestinal tract, and the bacterial adherence to the gastrointestinal cell line is influenced by the level of P-glycoprotein expression, which could be manipulated by the use of P-glycoprotein inducer or inhibitor (5,8).
A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression.
Toward a better pharmacophore description of P-glycoprotein modulators, based on macrocydic diterpenes from Euphorbia species.
Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols," Molecular Cancer, vol.
The P-glycoprotein and CYP3A inhibition pose a serious concern for the need to regulate or at least monitor cannabis use in patients receiving tacrolimus after HSCT.
Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.
Spontaneus canine transmissible venereal tumor: cell morphology and influence on p-glycoprotein expression.
Key Words: P-Glycoprotein, Blood brain barrier, Drug resistance.
Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients.