CDH3

(redirected from P-cadherin)

CDH3

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH3 is also a retired HUGO symbol for what is now designated CDH15, see there.

Molecular pathology
Loss of heterozygosity mutations of CDH3 occur in breast and prostate cancer; aberrant expression of cadherin 3 occurs in cervical adenocarcinomas. CDH3 mutation causes congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia with ectrodactyly and macular dystrophy.
References in periodicals archive ?
Williams et al, (13) found upregulation of P-cadherin expression in severe dysplasia and reduced expression of the E-cadherin and/or catenins in carcinoma in situ and infiltrating tumors.
P-cadherin is a protein that is over-expressed in many common types of cancer, including lung, pancreatic and colon cancers, and is implicated in tumor growth and cancer disease progression.
FF-21101 uses antibodies that target P-cadherin, which is over-expressed on the surface of solid cancer cells, and accumulated in lung cancer cells, pancreatic cancer cells, etc.
Other MEC markers, such as SMA, p-cadherin, Wilms tumor 1 (WT1), S100, and high-molecular-weight cytokeratin (HMWCK) or basal-type cytokeratin (CK) (CK5/6, CK14, CK17, CK903) are less commonly used because of marked cross-reactivity with myofibroblasts and vascular SMA, (4-9,19,20) frequent reactivity in tumor cells (HMWCK or basal-type CK, S100, p-cadherin), (4-8,19,32-34) or low sensitivity (WT1 and S100).
The expression of P-cadherin is restricted only to basal or lower layers of epithelia, including prostate and skin and also to breast myoepithelial cells (MECs).
Cell adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract.
E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice.
We demonstrated that while bi-layered organization in mammary epithelium is driven mainly by the lineage-specific differential expression of the E-cadherin adhesion protein, the expression of the P-cadherin adhesion protein makes additional contributions that are specific to the organization of the myoepithelial layer," LaBarge says.
These include p75, Wilm tumor-1 (WT-1), 14-3-3r, maspin, and P-cadherin.
These include CD109, (4,5) caveolin 1 and 2, (6,7) podoplanin, (8) P-cadherin, (9,10) maspin, (11-13) nestin, (14) p75, (15-17) 14-3-3 sigma (stratifin), (18) smooth muscle actin (SMA), (19) p63, (20) CD10, (21) smooth muscle myosin heavy chains (SMMHCs), (22,23) h-caldesmon, (23) calponin, (23) S100, (24-26) basal type and high-molecular-weight cytokeratins, (27) glial fibrillary acid protein, (28,29) metallothionein, (12) Wilms tumor 1 protein, (30) CD44s, (31) and vimentin, (32) among others.