CDH3

(redirected from P-cadherin)

CDH3

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH3 is also a retired HUGO symbol for what is now designated CDH15, see there.

Molecular pathology
Loss of heterozygosity mutations of CDH3 occur in breast and prostate cancer; aberrant expression of cadherin 3 occurs in cervical adenocarcinomas. CDH3 mutation causes congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia with ectrodactyly and macular dystrophy.
References in periodicals archive ?
The expression of P-cadherin is restricted only to basal or lower layers of epithelia, including prostate and skin and also to breast myoepithelial cells (MECs).
P-cadherin as myoepithelial cell marker for differential diagnosis of benign and malignant breast lesions.
These include CD109, (4,5) caveolin 1 and 2, (6,7) podoplanin, (8) P-cadherin, (9,10) maspin, (11-13) nestin, (14) p75, (15-17) 14-3-3 sigma (stratifin), (18) smooth muscle actin (SMA), (19) p63, (20) CD10, (21) smooth muscle myosin heavy chains (SMMHCs), (22,23) h-caldesmon, (23) calponin, (23) S100, (24-26) basal type and high-molecular-weight cytokeratins, (27) glial fibrillary acid protein, (28,29) metallothionein, (12) Wilms tumor 1 protein, (30) CD44s, (31) and vimentin, (32) among others.
The calcium-dependent intercellular adhesion molecule P-cadherin is reliably expressed in normal breast MECs and the MECs associated with noninvasive breast proliferations.
MSA, SMA, SMMHC, calponin, and p75 are expressed in vascular smooth muscle and/or pericytes, whereas basal-type and high-molecular-weight cytokeratins, maspin, and P-cadherin are generally negative in these cells.
Markers that most effectively combine sensitivity, specificity, and ease of interpretation include SMMHCs, calponin, p75, p63, P-cadherin, basal CKs, maspin, and CD10.
We demonstrated that while bi-layered organization in mammary epithelium is driven mainly by the lineage-specific differential expression of the E-cadherin adhesion protein, the expression of the P-cadherin adhesion protein makes additional contributions that are specific to the organization of the myoepithelial layer," LaBarge says.
25) In addition, basal-like breast carcinomas are positive for P-cadherin (83%) and p63 (55%) and are negative for B-cell lymphoma 2 (63%), whereas luminal subtype tumors are negative for P-cadherin (80%) and p63 (85%) and are positive for B-cell lym phoma 2 (56%).
16-19] These studies generally have examined E- and P-cadherin and have shown modulation and attentuation of these proteins in tumors.
E-cadherin was most frequently expressed (34/35, 97%), followed in frequency by N-cadherin (22/35, 63%) and P-cadherin (15/35, 43%).
E-Cadherin N-Cadherin P-Cadherin 1 mn + + 2 mn + + 3 mn + + 4 mn + + 5 mn + + 6 mn + + 7 mn + + 8 mn + + 9 mn + - 10 mn + - 11 mn + - 12 mn - + 13 mn - + 14 mn - + 15 mn - - 16 mn - - 17 mn - - 18 mn - - 19 n + + 20 n + + 21 n + - 22 n + - 23 n + - 24 n + - 25 n + - 26 n + - 27 n + - 28 n - - 29 n - - 30 n - - 31 n - - 32 n - - 33 m + + 34 m + - 35 - - -
This was in contrast to the expression of N-cadherin and P-cadherin that was observed in the plasma membrane but not in the nucleus (Figure 2).