P-glycoprotein

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glycoprotein

[gli″ko-pro´tēn]

any of a class of conjugated proteins consisting of a compound of protein with a carbohydrate group.

α1-acid glycoprotein an acute phase protein found in blood plasma, an indicator of tissue necrosis and inflammation. Called also orosomucoid.

P-glycoprotein a cell-surface protein occurring normally in the colon, small intestine, adrenal glands, kidney, and liver, and also expressed by tumor cells. It is a modulator of multidrug resistance, mediating the transport of antineoplastic agents out of tumor cells.

variable surface glycoprotein any of several glycoproteins that form the antigenic protein coating of Trypanosoma brucei. The organisms contain numerous genes encoding hundreds of such glycoproteins and, by expressing individual ones successively, evade the immune system of the host.

P-gly·co·pro·tein

(glī'kō-prō'tēn),

Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

Synonym(s): P-170

Farlex Partner Medical Dictionary © Farlex 2012

P-gly·co·pro·tein

(glī'kō-prō'tēn)

Protein associated with tumor multidrug resistance; acts as an energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

P-glycoprotein

A cell membrane pump that influences cellular uptake and release of chemicals. It affects the relative resistance or susceptibility of cells to drug therapy.