P-glycoprotein

(redirected from P-170)

glycoprotein

 [gli″ko-pro´tēn]
any of a class of conjugated proteins consisting of a compound of protein with a carbohydrate group.
α1-acid glycoprotein an acute phase protein found in blood plasma, an indicator of tissue necrosis and inflammation. Called also orosomucoid.
P-glycoprotein a cell-surface protein occurring normally in the colon, small intestine, adrenal glands, kidney, and liver, and also expressed by tumor cells. It is a modulator of multidrug resistance, mediating the transport of antineoplastic agents out of tumor cells.
variable surface glycoprotein any of several glycoproteins that form the antigenic protein coating of Trypanosoma brucei. The organisms contain numerous genes encoding hundreds of such glycoproteins and, by expressing individual ones successively, evade the immune system of the host.

P-gly·co·pro·tein

(glī'kō-prō'tēn),
Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.
Synonym(s): P-170

P-gly·co·pro·tein

(glī'kō-prō'tēn)
Protein associated with tumor multidrug resistance; acts as an energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

P-glycoprotein

A cell membrane pump that influences cellular uptake and release of chemicals. It affects the relative resistance or susceptibility of cells to drug therapy.
See also: glycoprotein
References in periodicals archive ?
Proposed mechanisms for such drug resistance include gene amplification, where multiple copies of key genes are made by the cancer cell as protection, and the presence of a cellular protein called P-glycoprotein, or P-170 (SN: 1/3/87, p.
After discovering P-170 in the mid-1970s, scientists noted that presence of the human MDR1 gene coding for the protein can confer multidrug resistance.
Tenders are invited for Spl Repair Of Bldg No P-170 08 Nos Or Qtr At Talwar Line Bldg No P-16 At Cheerbagh T-99 At Signal Centre And Certain Revenue Works Under Age B/R Ii Of Ge Dehradun
Tenders are invited for Spl Repairs (Bldg) To Repair / Replacement Of Old Aluminium Wiring In Bldg No P-169, P-170, P-249 To P-252 (Trainees Practical Sheds) At Ciw Meg And Centre Under Ge (North) Bangalore
Tenders are invited for Special Repairs To Single Or Living Accn In Bldg No P-170 And P-171 At Arty Centre Under Ge Nasik Road
Tenders are invited for Spl Repair To Road Near Bldg No P-168 And P-170 And Fencing Around Bldg No P-170 At Naidu Enclave And Certain Misc B&R Work At Old Cantt Allahabad