OCA2

(redirected from P protein)

OCA2

A gene on chromosome 15q11.2-q12 that encodes a protein which may be involved in tyrosine transport within melanocyte and play a role in regulating the pH of melanosomes and melanosome maturation, as well as in post-translational processing of tyrosinase, which catalyses the limiting reaction in melanin synthesis. OCA2 may serve as a key control point at which skin colour variation is determined; it is a major determinant of brown and/or blue eye colour.

Molecular pathology
Defects in OCA2  cause oculocutaneous albinism type 2, see there.
References in periodicals archive ?
A marked increase in P protein subunit of glycine decarboxylase (spot 14, 2.0-fold in 100 [micro]M and 2.5-fold in 150 [micro]M) was found in As stressed plants, this being more significant in case of 150 [micro]M As treatment.
A marked increase in P protein subunit of glycine associated with photorespiration was found in 150 mM As-stressed plants.