oxidative phosphorylation

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phosphorylation

 [fos″for-ĭ-la´shun]
the process of introducing a phosphate group into an organic molecule.
oxidative phosphorylation the final common pathway of aerobic energy metabolism in which high-energy phosphate bonds are formed by phosphorylation of ADP to ATP coupled with the transfer of electrons along a chain of carrier proteins with molecular oxygen as the final acceptor. It occurs in mitochondria.

ox·i·da·tive phos·phor·y·la·tion

formation of high-energy phosphoric bonds (for example, in pyrophosphates) from the energy released by the flow of electrons to O2 and the dehydrogenation (i.e., oxidation) of various substrates, most notably isocitric acid, α-ketoglutaric acid, succinic acid, and malic acid in the tricarboxylic acid cycle.

oxidative phosphorylation

n.
The process in cell metabolism by which respiratory enzymes in the mitochondria synthesize ATP from ADP and inorganic phosphate during the oxidation of NADH by molecular oxygen.

oxidative phosphorylation

The formation of ATP within mitochondria using energy derived from the electron transport chain

ox·i·da·tive phos·phor·y·la·tion

(ok'si-dā'tiv fos'fōr-i-lā'shŭn)
Formation of high energy phosphoric bonds from the energy released by the dehydrogenation (i.e., oxidation) of various substrates.

oxidative phosphorylation

The process of cellular respiration occurring within the MITOCHONDRIA and responsible for the production of adenosine triphosphate (ATP). In this process energy derived from the oxidation of hydrogen, to form water, is transferred to ATP.

oxidative phosphorylation

a process that takes place in the ELECTRON TRANSPORT SYSTEM of aerobic respiration, in which ATP molecules are synthesized from ADP and inorganic phosphate. The process is the major means by which aerobic organisms obtain their energy from foodstuffs.
References in periodicals archive ?
The expression levels of porin and the OXPHOS complexes from normal tissue adjacent to cancerous tissue did not differ between HP-infected and noninfected samples.
Inhibitors of the entire pathway from pyruvate import to ATP export, and several steps in between (the MEGS), reduced oxygen consumption in fibroblasts and isolated muscle mitochondria, confirming that the integrity of the entire OXPHOS machinery can be tested successfully in both permeabilized cells and isolated mitochondria.
This process may be due to ROS induced damage to the mitochondrial genome as ROS are byproduct of OXPHOS system.
The flux was measured as the rate of [O.sub.2] consumption in permeabilized tissues derived from HCC patients when all components of the OXPHOS system were titrated with specific irreversible or pseudoirreversible inhibitors to stepwise decrease selected respiratory chain complex activities according to a previously published method [26, 27, 47, 48].
The energy produced by OXPHOS causes protons (particles with positive electric charge) to be transported across the inner mitochondrial membrane.
CD4 helper Th1, Th2, and Th17 specifically rely on glycolysis rather than mitochondrial metabolism, while T helper regulatory cells (Treg) show a parallel requirement for lipid metabolism, glycolysis, and OXPHOS [42-44].
In proliferating myoblasts, approximately 30% of the ATP used by the cells is provided by OXPHOS, whereas terminally differentiated myotubes rely on mitochondrial respiration as their major source of metabolic energy (approximately 60%) [25].
Because lidocaine can influence some OXPHOS enzymes (15,16), a minimal dose of lidocaine was used and biopsies were taken at some distance from the incision.
Metformin causes a switch from OXPHOS to aerobic glycolysis [97].
Retinoic acid-induced human ESC differentiation results in reduced UCP2 expression, accompanied by decreased glycolysis and increased OXPHOS [84].
The evolution of the electron transport chain (ETC) together with ATP synthase--a series of large multisubunit protein complexes responsible for oxidative phosphorylation (OxPhos)--was pivotal in this development, increasing the amount of adenine triphosphate (ATP) generated from the oxidation of glucose by ~15-fold compared to fermentative processes [2].
Mitochondria are the main component of the cell energy metabolism where oxidative phosphorylation (OXPHOS) takes place within cells; they are also involved in calcium ion flux regulation, apoptosis regulation, and intracellular signalling.