alpha-ketoglutaric acid

(redirected from Oxoglutarate)

α-ketoglutaric acid

/α-ke·to·glu·tar·ic ac·id/ (-gloo-tar´ik) a metabolic intermediate involved in the tricarboxylic acid cycle, in amino acid metabolism, and in transamination reactions as an amino group acceptor.

α-ketoglutaric acid

2-oxoglutaric acid; intermediate of TCA cycle.
References in periodicals archive ?
Others have shown that BPA exposure alters expression of key mitochondrial genes such as oxoglutarate dehydrogenase (Ogdh) and uncoupling protein 2 (Ucp2) in rodent islets (Wei et al.
There are additional findings in mitochondria affected by AD such as lower activity of pyruvate dehydrogenase (PDH) and oxoglutarate dehydrogenase (OGDH) [104, 132].
AST catalyzes the transfer of amino group from aspartate to oxoglutarate with formation of glutamate and oxaloacetate.
The addition of TMZ to the cardioplegic solution partially protected oxoglutarate (and succinate) mitochondrial respiration and induced an increase in Ca2+ triggered NADH formation.
A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects.
Transaminase activities are based on the formation of oxaloacetate (GOT) or pyruvate (GPT) from aspartate and alanine, respectively, with 2, oxoglutarate.
Its assimilation is then enabled by the coupled action of the enzymes glutamate synthetase (glutamine: 2 oxoglutarate amido-transferase [GOGAT]) and glutamine synthetase (GS) (Ka-meya et al, 2006, 2007).
In a double-blind trial, 194 ambulatory elderly patients (mean age, 74 [+ or -] 8 years) recovering from acute illnesses were randomly assigned to receive either ornithine oxoglutarate (OGO) or a placebo.
The synthesis of 2- oxoglutarate (2-OG) is catalyzed by isocitrate dehydrogenase (IDH), one of the key enzymes in the TCA cycle.
2+] could activate three dehydrogenases of the TCA cycle (pyruvate dehydrogenase, isocitrate dehydrogenase, and oxoglutarate dehydrogenase), the ATP synthase (complex V), and the adenine nucleotide translocase and then increase the generation of ROS [106-108].
The difference in glutamate production between two Corynebacterium spp was caused by the difference in the degree of decrease in oxoglutarate dehdrogenase complex (ODHC) specific activity, along with difference in Km values of isocitrate dehydrogenase, glutamate dehydrogenase, and ODHC explained the mechanism of flux redistribution at the branch point of 2-oxoglutarate (Shirai et al.
The TCA cycle is also a factory for intermediates with oxoglutarate serving as precursor to porphyrins (chlorophyll, cytochrome) and amino acids (and thus protein).