Others have shown that BPA exposure alters expression of key mitochondrial genes such as oxoglutarate
dehydrogenase (Ogdh) and uncoupling protein 2 (Ucp2) in rodent islets (Wei et al.
There are additional findings in mitochondria affected by AD such as lower activity of pyruvate dehydrogenase (PDH) and oxoglutarate
dehydrogenase (OGDH) [104, 132].
AST catalyzes the transfer of amino group from aspartate to oxoglutarate
with formation of glutamate and oxaloacetate.
The addition of TMZ to the cardioplegic solution partially protected oxoglutarate
(and succinate) mitochondrial respiration and induced an increase in Ca2+ triggered NADH formation.
A two-centre, randomized, double-blind trial of ornithine oxoglutarate
in 194 elderly, ambulatory, convalescent subjects.
Transaminase activities are based on the formation of oxaloacetate (GOT) or pyruvate (GPT) from aspartate and alanine, respectively, with 2, oxoglutarate
Its assimilation is then enabled by the coupled action of the enzymes glutamate synthetase (glutamine: 2 oxoglutarate
amido-transferase [GOGAT]) and glutamine synthetase (GS) (Ka-meya et al, 2006, 2007).
In a double-blind trial, 194 ambulatory elderly patients (mean age, 74 [+ or -] 8 years) recovering from acute illnesses were randomly assigned to receive either ornithine oxoglutarate
(OGO) or a placebo.
The synthesis of 2- oxoglutarate
(2-OG) is catalyzed by isocitrate dehydrogenase (IDH), one of the key enzymes in the TCA cycle.
2+] could activate three dehydrogenases of the TCA cycle (pyruvate dehydrogenase, isocitrate dehydrogenase, and oxoglutarate
dehydrogenase), the ATP synthase (complex V), and the adenine nucleotide translocase and then increase the generation of ROS [106-108].
The difference in glutamate production between two Corynebacterium spp was caused by the difference in the degree of decrease in oxoglutarate
dehdrogenase complex (ODHC) specific activity, along with difference in Km values of isocitrate dehydrogenase, glutamate dehydrogenase, and ODHC explained the mechanism of flux redistribution at the branch point of 2-oxoglutarate
(Shirai et al.
The TCA cycle is also a factory for intermediates with oxoglutarate
serving as precursor to porphyrins (chlorophyll, cytochrome) and amino acids (and thus protein).