The development of oxidative metabolism
in plants begins as a response to a large number of factors, both biotic and abiotic (Mehdy et al.
In studies of the oxidative metabolism
of BDE-47 and BDE-99 in rat hepatic microsomes, OH-PBDE metabolites were identified for both BDE congeners (Erratico et al.
The rate of oxidative metabolism
was 21-fold higher compared with the rate of nonoxidative metabolism (Haber et al.
There is also a 15%-20% decrease in oxidative metabolism
between young and old adults in drugs that use the cytochrome P450 system for oxidization and inactivation.
SPECT and PET tracers have been developed to measure oxidative metabolism
, fatty acid and amino acid metabolism, and pre- and post-synaptic receptor densities.
It has been hypothesized that this is due to inefficient oxidative metabolism
in the limbic system and brainstem where the control mechanisms dominate.
A group of 33 dogs undergoing openchest left anterior descending coronary artery (LAD) ligation causing prolonged ischemia were imaged with quantitative positron emission tomography (PET) using 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) to measure regional glucose metabolic utilization (rGMU) and [11C]acetate to measure regional monoexponential washout rate constant (Kmono) for oxidative metabolism
in nonrisk and ischemic-risk myocardium.
Environmental oxidative stress can also involve the depletion of cellular antioxidant defense mechanisms or dysregulation of oxidative metabolism
processes in the cell (Ercal et al.
As shown in Figure 1, ADH, cytochrome P450 2E1 (CYP2E1), and catalase all contribute to oxidative metabolism
CYP 1A2 is the principle isoenzyme involved in the initial oxidative metabolism
For more than 80 years it has been known that cancer cells generate their energy principally by glycolytic metabolism rather than by oxidative metabolism
, the latter being the primary energy source in healthy cells.
GLA is further metabolized to dihomogamma linlenic acid (DGLA) which undergoes oxidative metabolism
by cyclooxygenases and lipoxygenases to produce anti-inflammatory eicosanoids (prostaglandins of series 1 and leukotrienes of series 3).