The peroxidation of leukocytes index ratio (PLIR) measures the resistance of leukocytes to exogenous oxidative stress and their functional capacity of
oxidative burst upon activation [14].
The results obtained in this study highlight a short-term oxidative DNA damage induced by CABG procedure in CAD patients and a complete recovery of this
oxidative burst six months after the procedure.
In contrast, CD137, a costimulatory immune checkpoint molecule, could reduce typical macrophage characteristics such as phagocytosis,
oxidative burst, and CD14 expression, which could induce the differentiation of monocytes to dendritic cells (DC) and DC maturation and reduce ROS generation [39].
Additionally,
oxidative burst is also required in the clearance of apoptotic cells by alternatively activated macrophages during wound healing process [53].
The reduced muscle damage response in NAC may be further explained by previous observations of attenuated eccentric exercise-induced muscle injury following neutrophil and macrophage depletion suggesting that neutrophil's/macrophages'
oxidative burst maybe responsible for part of muscle's injury during early recovery [32, 61].
In this context, although oxidative stress is involved in metabolic syndrome, decreases in
oxidative burst of neutrophils occurred in some conditions, such as hypercholesterolemia [8] and non-insulin-dependent diabetes mellitus (NIDDM) [9].
In addition, they focus on mitochondria-targeted MitoQ and SkQ antioxidants and propose astaxanthin, a carotenoid, for acute inflammatory conditions characterized by pathologically increased
oxidative burst, for example, avian influenza with acute respiratory distress syndrome and ischemia-reperfusion.
Nabinger et al., "Protein-tyrosine phosphatase Shp2 positively regulates macrophage
oxidative burst," Journal of Biological Chemistry, vol.
The antigen receptors are themselves OS-generating enzymes, contributing further to enhancing the cellular "
oxidative burst" against exogenous pathogens as well as neighbouring cells [10], causing autoinflammatory and/or allergic diseases [17, 38].
Thaler, "
Oxidative burst of neutrophils in patients with rheumatoid arthritis: influence of various cytokines and medication," Clinical and Experimental Rheumatology, vol.
The massive production of antimicrobial and tumoricidal ROS in an inflammatory environment is called "
oxidative burst" and plays an important role as the first line of defense against environmental pathogens.
In the response to various stimuli, the cells produce a large variety of ROS ([O.sub.2.sup.*-], [H.sub.2][O.sub.2], H[O.sup.*], hypochlorous acid (HOCl), and N-chloroamines (R-NHCl)) during a process called the
oxidative burst in order to kill pathogens.
