The present study was conducted to determine the susceptibility of MRSA isolates to various classes of anti-MRSA drugs such as vancomycin (glycopeptide), daptomycin (lipopeptide), tigecycline (glycylcycline) and linezolid (oxazolidinone
) to determine the [MIC.sub.50] and [MIC.sub.90] values and to observe MIC creep, if any, with respect to these drugs.
The finding is of concern, because linezolid--the first approved oxazolidinone
, which is the first new class of antibacterial agents introduced since 1980--has activity against a number of important organisms.
Linezolid is the first antibiotic in the oxazolidinone
The company's key investigational drug, tedizolid phosphate, is a once daily, IV and orally administered second generation oxazolidinone
in Phase III clinical trial for the treatment of acute bacterial skin and skin structure infections.
More than 40% of patients in this cohort received off-label treatment against MDR or XDR TB with the oxazolidinone
In the 796 recipients of linezolid--the first Food and Drug Administration-approved oxazolidinone
antibiotic--infections included osteomyelitis, complicated skin infections, endocarditis, bacteremia, and intraabdominal infections.
Linezolid belongs to the oxazolidinone
class of antibiotics, which act by disrupting the start of bacterial protein synthesis.
Also reviewed are potential new antimicrobial agents currently undergoing investigation, such as the novel oxazolidinone
RWJ-416457, the new glycopeptide dalbavancin, the glycylcycline compound tigecycline, the new carbacephem BP-102 and novel rifamycin derivatives.
Linezolid, 1 of the oxazolidinone
class of antimicrobial drugs, inhibits bacterial protein synthesis by binding to the 50S subunit of 23S rRNA.
The first available oxazolidinone
was as effective as vancomycin for the treatment of methicillin-resistant Staphylococcus aureus in a randomized, multicenter, open-label trial.
All our MRSA isolates were also found to be sensitive to Linezolid which is the first oxazolidinone
antibiotic approved for treatment of Gram-positive infections.
Linezolid, an oxazolidinone
antibiotic, is indicated for the treatment of MRSA in nosocomial pneumonia and complicated SSTI infections, including diabetic foot infections, without concomitant osteomyelitis.