sulfacetamide sodium

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sulfacetamide sodium

Bleph-10, Diosulf (CA), Klaron, PMS-Sulfacetamide (CA)

Pharmacologic class: Sulfonamide

Therapeutic class: Anti-infective

Pregnancy risk category C

Action

Inhibits bacterial synthesis of folic acid by preventing condensation of pteridine with aminobenzoic acid through competitive inhibition of dihydropteroate synthetase

Availability

Lotion: 10% in 2-oz and 4-oz bottles

Ophthalmic solution: 10% in 5-ml and 15-ml dropper bottles

Indications and dosages

Acne vulgaris

Adults and children ages 12 and older: Apply thin film topically to affected areas b.i.d.

Superficial ocular infections (including conjunctivitis)

Adults and children ages 2 months and older: Initially, apply one to two drops of ophthalmic solution into conjunctival sac of affected eye q 2 to 3 hours. Taper by increasing dosing intervals as condition responds. Usual duration is 7 to 10 days.

Adjunct in trachoma

Adults: Apply two drops of ophthalmic solution into conjunctival sac of affected eye q 2 hours; must be accompanied by systemic sulfonamide therapy.

Contraindications

• Hypersensitivity to drug or other sulfonamides

Precautions

Use cautiously in:
• sulfite allergy
• dry eye syndrome.

Administration

• To avoid contamination, don't touch container tip to eye, eyelid, or any other surface.

Adverse reactions

EENT: conjunctival hyperemia, eye burning, stinging, tearing (ophthalmic form)

Skin: local irritation, erythema, itching and edema (topical form), photosensitivity reaction

Other: secondary infections

Interactions

Drug-drug.Porfimer: increased severity of photosensitivity reaction, leading to excessive tissue damage

Silver preparations: precipitation

Patient monitoring

• Monitor patient for drug efficacy. Know that drug may be inactivated by purulent exudate.

Patient teaching

• Tell patient to apply a thin film of lotion to affected areas, as prescribed.
• Teach patient how to apply ophthalmic form. Instruct him to always wash hands first and to clean eye area of discharge by wiping from inner to outer area before applying.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

sulfacetamide sodium 

An anti-infective, bacteriostatic drug of the sulfonamide family, used topically against infections and injuries, as well as minor abrasions, of the conjunctiva and cornea. It should not be used immediately following a local anaesthetic. However, antibiotics (e.g. bacitracin, chloramphenicol, erythromycin, gentamicin, neomycin, norfloxacin, polymyxin B, tetracycline, tobramycin), which inhibit or destroy a wide range of microorganisms are used more commonly than local sulfonamides. See antibiotic; antifungal agent; antiinflammatory drug; bacteriostatic; sulfonamide.

sulfacetamide sodium (ophthalmic),

n brand names: Bleph-10, Cetamide, Isopto Cetamide;
drug class: antibacterial sulfonamide;
action: inhibits folic acid synthesis by preventing paraaminobenzoic acid (PABA) use, which is necessary for bacterial growth;
uses: treatment of conjunctivitis, superficial eye infections, and corneal ulcers.
References in periodicals archive ?
To help bring a treatment option to people afflicted with common skin disorders including SD, Mission Pharmacal Company is adding Ovace Plus Lotion (sodium sulfacetamide 9.
Ovace Plus Lotion joins Ovace Plus Wash (sodium sulfacetamide 10%) Cleansing Gel and Ovace Plus Shampoo (sodium sulfacetamide 10%) formulated with the proven action of sodium sulfacetamide for SD, seborrhea sicca (dandruff), and infections of the skin caused by sulfonamide-susceptible bacteria.
In addition, Ovace products provide physicians and their patients with the added assurance of being manufactured in the U.
Ovace (sodium sulfacetamide 10%) Wash is indicated for the treatment of seborrheic dermatitis of the face.