sulfacetamide sodium

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sulfacetamide sodium

Bleph-10, Diosulf (CA), Klaron, PMS-Sulfacetamide (CA)

Pharmacologic class: Sulfonamide

Therapeutic class: Anti-infective

Pregnancy risk category C

Action

Inhibits bacterial synthesis of folic acid by preventing condensation of pteridine with aminobenzoic acid through competitive inhibition of dihydropteroate synthetase

Availability

Lotion: 10% in 2-oz and 4-oz bottles

Ophthalmic solution: 10% in 5-ml and 15-ml dropper bottles

Indications and dosages

Acne vulgaris

Adults and children ages 12 and older: Apply thin film topically to affected areas b.i.d.

Superficial ocular infections (including conjunctivitis)

Adults and children ages 2 months and older: Initially, apply one to two drops of ophthalmic solution into conjunctival sac of affected eye q 2 to 3 hours. Taper by increasing dosing intervals as condition responds. Usual duration is 7 to 10 days.

Adjunct in trachoma

Adults: Apply two drops of ophthalmic solution into conjunctival sac of affected eye q 2 hours; must be accompanied by systemic sulfonamide therapy.

Contraindications

• Hypersensitivity to drug or other sulfonamides

Precautions

Use cautiously in:
• sulfite allergy
• dry eye syndrome.

Administration

• To avoid contamination, don't touch container tip to eye, eyelid, or any other surface.

Adverse reactions

EENT: conjunctival hyperemia, eye burning, stinging, tearing (ophthalmic form)

Skin: local irritation, erythema, itching and edema (topical form), photosensitivity reaction

Other: secondary infections

Interactions

Drug-drug.Porfimer: increased severity of photosensitivity reaction, leading to excessive tissue damage

Silver preparations: precipitation

Patient monitoring

• Monitor patient for drug efficacy. Know that drug may be inactivated by purulent exudate.

Patient teaching

• Tell patient to apply a thin film of lotion to affected areas, as prescribed.
• Teach patient how to apply ophthalmic form. Instruct him to always wash hands first and to clean eye area of discharge by wiping from inner to outer area before applying.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

sulfacetamide sodium 

An anti-infective, bacteriostatic drug of the sulfonamide family, used topically against infections and injuries, as well as minor abrasions, of the conjunctiva and cornea. It should not be used immediately following a local anaesthetic. However, antibiotics (e.g. bacitracin, chloramphenicol, erythromycin, gentamicin, neomycin, norfloxacin, polymyxin B, tetracycline, tobramycin), which inhibit or destroy a wide range of microorganisms are used more commonly than local sulfonamides. See antibiotic; antifungal agent; antiinflammatory drug; bacteriostatic; sulfonamide.

sulfacetamide sodium (ophthalmic),

n brand names: Bleph-10, Cetamide, Isopto Cetamide;
drug class: antibacterial sulfonamide;
action: inhibits folic acid synthesis by preventing paraaminobenzoic acid (PABA) use, which is necessary for bacterial growth;
uses: treatment of conjunctivitis, superficial eye infections, and corneal ulcers.
References in periodicals archive ?
En Colombia no se conoce la incidencia de muerte por OVACE, por lo cual se toma como referencia la incidencia de muerte en Estados Unidos que es de 0,66 por cada 100.
Por esta razon la intervencion sobre la OVACE debe ser rapida, eficaz, profesional y adecuada, y debe responder a las expectativas de la comunidad ya sea por parte del personal medico como de cualquier otra persona que maneje el caso como primer respondiente.
Por ejemplo, en un paciente que este comiendo o tenga algun objeto en su boca, y que subitamente presente tos, dificultad para respirar, su respiracion se torna ruidosa, muestra imposibilidad para hablar, la tos se vuelva inefectiva y silenciosa, se lleva las manos al cuello y pierde la conciencia, la probabilidad de una OVACE es bastante alta.
7,8) De acuerdo con los reportes de la literatura, aproximadamente el 50% de casos de OVACE fueron exitosamente resueltos con mas de una tecnica; de ahi que este indicado no solo realizar compresiones toracicas, sino tambien la maniobra de Heimlich.
Healthpoint has introduced a number of innovative products over the past three years, including Salex cream and lotion; Ovace wash and foam for seborrheic dermatitis; Cloderm, Akne-Mycin for acne treatment; and TheraSeal, a hand protectant.
Over the past three years, he notes, the company has introduced several products that it feels are innovative, including Salex, a 6% salicylic acid cream and lotion; Ovace, a foam, cream, gel and wash formulated with 10% sodium sulfacetamide; and TheraSeal hand protectant.
Ovace (sodium sulfacetamide 10%) Wash is indicated for the treatment of seborrheic dermatitis of the face.
has introduced new formulations in its Ovace line of products for treating seborrheic dermatitis, which affects as many as 14 million Americans.
Other Ovace products include a wash for the face and a foam for the scalp.
Ovace cream and Ovace gel are important advances designed to bring the unique advantages of Ovace to patients with either dry or oily skin," states Christopher Hensby, vice president of research and development.
Ovace cream and Ovace gel are expected to achieve rapid acceptance, allowing greater prescribing flexibility for optimal clinical results and patient compliance.
has unveiled Ovace foam as a treatment for seborrheic dermatitis of the scalp.