Osteoconduction


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Osteoconduction

Provision of a scaffold for the growth of new bone.
Mentioned in: Bone Grafting
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The scaffold must be highly biocompatible, biodegradable, bioactive, and during healing it must promote osteoconduction, osteoinduction and osteogenesis.
(26,31) PLA scaffolds with 300 micron pores have been shown to promote osteoconduction for calvarial defects.
DiFusion Technologies, an Austin, Texas-based provider of advanced biomaterials, has created a hybrid PEEK material that dramatically enhances osteoconduction, according to early studies.
(3) Bioactive ceramics such as hydroxyapatite (HA) are helpful in the restoration of the bone with satisfying osteoinduction, osteocompatibility, and osteoconduction properties (34) without triggering a considerable immune response.
Osteoconduction, Osteogenicity, Osteoinduction, what are the fundamental properties for a smart bone substitutes.
Depending on the type of graft chosen, its function will be a mechanic support and osteoconduction. Thus, the incorporation time is delayed and with complications risk (4).
The three fundamental properties of bone regeneration are osteogenesis, osteoinduction, and osteoconduction. Osteogenesis is defined as the formation of bone, and the "osteogenic" potential of a graft is its ability to provide appropriate cellular environment where the osteoprogenitor cells could survive transplantation and proliferate and differentiate into osteoblasts and osteocytes [10].
Over time, with the presence of phosphate ions in the surroundings, osteoconduction occurs with hydroxyapatite crystal-like structures being deposited over the placed ERRM material, and this results in the apical barrier formation.
The iliac crest holds a reservoir of spongious bone that is frequently used as a source of bone autograft, providing extracellular matrix (for osteoconduction), growth factors (modulating bone healing as per osteoinduction), and patient's cells (leading to local osteogenesis).
It was concluded that the irradiated surfaces undergo considerable changes in surface properties including wettability, mechanical and electrical properties, as well as exhibited unique bioactivity, forming spherical macro-porous apatite layer which can enhance osteointegration and osteoconduction. The irradiation and ion implantation approach also helps in the surface functionalization of bio-inert titanium implants.