Osteoclasts


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Osteoclasts

Bone cells that break down and remove bone tissue.
References in periodicals archive ?
Bone homeostasis is maintained by balanced production of osteoblasts and osteoclasts. Disruption of this balance can convert normal niches into metastatic niches.
CCL3 also functions as a chemotactic molecule for mature osteoclasts (13) and osteoclast precursor cells (14).
A three-dimensional tissue culture model of bone formation utilizing rotational co-culture of human adult osteoblasts and osteoclasts. Acta Biomater.
Monocyte's Journey from Blood to Bone to Become Osteoclasts
Osteoclasts that trigger the bone remodeling cycle are formed by the fusion of mononuclear progenitors in osteoclastogenesis [2].
* But with aging, loss of sex hormones (estrogen and testosterone), and oxidative stress, the activity of bone-forming osteoblasts diminishes, while bone resorption by osteoclasts continues at the same rate, or even increases.
The results of this study corroborate the findings of Suzuki et al., showing that the in vitro addition of low doses of PTH to the culture medium promotes an increase in the resorptive activity of osteoclasts, and suggests that the activities of osteoblasts and osteoclasts are coupled.
The hormone stimulates the cells in bones that break down bone and create new bone (osteoblasts and osteoclasts), but the hormone has a greater impact on cells that create new bone.
Once metastatic breast cancer cells enter into the bone microenvironment, they disturb the normal regulatory mechanisms associated with bone remodeling process by inducing activation of bone-resorbing osteoclasts [6].
These cells and cytokines also induce the production of matrix metalloproteinases (MMP) as well as the maturation and activation of osteoclasts, which promote destruction of cartilage and bone, respectively.
Rejection reactions were checked by counting the amount of Immunoglobulin-G in serological reactions and then the amount of microvascular, osteoclasts, osteoblasts, bone, and broad woven fibrous tissue surrounding the graft at 100x and 400x magnification for histopathological examination and also VEGF and Immunoglobulin-G for immunohistochemistry examination was calculated.