Osteoclasts


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Osteoclasts

Bone cells that break down and remove bone tissue.
References in periodicals archive ?
Next, 50 [micro]l of chromogenic substrate was added to each well, and the osteoclasts were observed under a microscope (Rana et al.
This protein is able to bind to RANK receptors on osteoclasts and prevent the binding of RANKL.
The ability of the cells to differentiate into osteoclasts will verified using the same techniques as described during the bulk addition of proteins.
Although it is believed that osteolysis during aseptic loosening is most likely due to increased bone resorption by osteoclasts [20], it remains unclear if there is a correlation between the osteoclast number and the extent of PIO.
Cathepsin K is a lysosomal cysteine protease that is selectively expressed by osteoclasts and contributes to the breakdown of the bone matrix.
5) Odanacatib appears to mainly suppress bone resorption with only a transient effect on bone formation and does not seem to impact osteoclast survival.
Several theories suggest ONJ likely results from a combination of the induction of osteoclast and oral mucosa keratinocyte apoptosis, and the inhibitory effects upon VEGF.
Binding of RANKL to RANK on the surfaces of osteoclast precursors will trigger maturation, activation, and prolonged survival of these cells.
Peptan modulates bone formation by stimulating osteoblast growth and differentiation while reducing osteoclast activity.
Bone is a living tissue that constantly repairs itself - a process regulated by cells called osteoblasts which form new bone and osteoclasts which remove old bone.