Osteoclasts


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Osteoclasts

Bone cells that break down and remove bone tissue.
References in periodicals archive ?
Osteoclasts are multinucleated cells derived from the mononuclear precursors in the myeloid lineage of hematopoietic cells.
After staining with hematoxylin and eosin, number of osteoclasts (multinuclear cells in the resorption lacunae close to the bone surface) were quantified under x 40 magnifications in five consecutive microscopic fields by two histopathologist.
OP is class of bone diseases, with characteristic features such as osteoclast failure and defective bone resorption.
Hurtel-Lemaire has shown that strontium can induce apoptosis of osteoclasts via the CaSR but in a different manner than that when calcium stimulates the CaSR This, in turn, induces apoptosis of mature osteoclasts (18), which serves as a key step in the regulation of overall osteoclast activity and thereby in the process of bone resorption(19).
Osteoclasts develop from blood stem cells and act to break down bone matrix, accumulating in areas of microdamage in both cortical and trabecular bone.
TRAF2, -5, and -6 all bind to RANK, but of these only TRAF6 appears to be essential in osteoclasts formation.
In 2007, a novel study was conducted by Simpson et al, in which they used mature osteoclasts to demineralize calcified elastin in vitro and in vivo [2].
Because osteoclasts play a role in stimulating bone formation by osteoblasts, these treatments indirectly lower bone formation.
The balance between the amount of bone matrix produced by osteoblasts and bone resorption by osteoclasts is essential for proper bone metabolism.
During bone metastasis, tumors invade the bone and take over the cells known as osteoclasts that normally break down old bone material as new material grows.
Bone is a dynamic tissue that is constantly formed by osteoblasts and resorbed by osteoclasts, which maintain a dynamic balance on the principle that the amount of bone destroyed by osteoclasts is equal to the amount of bone formed by osteoblasts.