Osteoblasts


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Osteoblasts

Cells in the body that build new bone tissue.
References in periodicals archive ?
This form of osteoporosis is called postmenopausal osteoporosis (PO).[4] An imbalance of osteoblasts and osteoclasts in the bone causes osteoporosis.[5] PO has become one of the most important diseases that affect elder women, as it entails huge financial burdens for individuals and society, and reduces the quality of life.
A three-dimensional tissue culture model of bone formation utilizing rotational co-culture of human adult osteoblasts and osteoclasts.
miR-21 affects both osteoclasts and osteoblasts. This miRNA is highly expressed during osteoclastogenesis and promotes the differentiation of murine BMMs through the downregulation of PDCD4 (a repressor of OC differentiation) and the survival of mature osteoclasts by the downregulation of FasL (involved in the Fas/FasL pro-apoptotic pathway [41].
Wang et al., "Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies," European Cells and Materials, vol.
MC3T3-E1 cells, which are osteoblasts derived from mouse calvaria [36-38], were seeded in 10 cm plastic cell culture plates (Becton Dickinson, Franklin Lakes, NJ, USA) at 1.5 x [10.sup.5] cells per plate in a-minimum essential medium (a-MEM; Invitrogen, Grand Island, NY, USA) containing 10% inactivated fetal bovine serum (FBS; Bio West, Miami, FL, USA) and 1% penicillin G-streptomycin sulfate (Invitrogen).
The main aim of this study was to investigate the putative association among the presence of prostate cancer cells, defined as prostate osteoblast-like cells (POLCs), and showing the expression of typical morphological and molecular characteristics of osteoblasts, the development of bone metastasis within 5 years of diagnosis, and the uptake of [sup.18]F-choline evaluated by PET/CT analysis.
Osteoblasts undergo several stages before maturation and mineralization of bone matrix.
Adult BMSCs can differentiate into many cell types such as adipocytes, osteoblasts, and chondrocytes in the bone.
ALP is a homodimeric glycoprotein secreted by osteoblasts, and the degree of secretion is related to the degree of differentiation of the osteoblasts [43].
hOST: Primary human osteoblasts (hOST, Lonza, Switzerland) were cultured in osteoblast growth medium (OGM, Lonza, Switzerland) which maintains the proliferative phenotype.
In bone tissue, PTH increases osteoclast formation and bone resorption by regulating the receptor activator of nuclear factor kappa B ligant (RANKL)/osteoprotegerin (OPG) expressed in osteoblasts. Moreover, it is also reported that PTH may have an anabolic effect on bone tissue, which increases bone mass (Del Fattore et al., 2008).
It has the ability to stimulate the differentiation and proliferation of osteoblasts and inhibiting osteoclast formation from bone marrow11.