ARID1B

ARID1B

A gene on chromosome 6q25.3 that encodes an AT-rich interactive domain-containing protein, which is highly expressed in the heart, skeletal muscle and kidneys. ARID1B is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

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