organotin

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organotin

Any tin-based organic compound in wide use for marine anti-fouling paints, wood catalysts, plasticisers, slimicides, in industrial water systems and as fungicides. Human exposure results from contaminated seafood, agricultural products and drinking water. Blood levels of organotins may be high enough to act on retinoid X receptors and PPAR gamma, upregulating the adipogenic signalling pathway, which explains organotins’ obesogenic effects.
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The organotin compound trimethyltin (TMT) is increasingly exploited as a model neurotoxicant in order to study the effects of chemical exposure on behavior and hippocampal function.
Concentrations of organotin compounds and imposex in the gastropod Hexaplex trunculus from the Lagoon of Venice.
The great uncertainty of organotin compounds lies in their structural and functional diversity, water solubility, hydrolysis, partition-coefficient and fate of the compounds in environment and biological system.
Ships with uncontained organotin compounds on their hulls in January 2008 will be in violation of the EU requirements and could be denied entry to EU ports irrespective of the treaty's status.
The Anti-Fouling Working Group is working to have countries ratify and comply with the treaty as concern is heightened by the treaty's looming January 2008 deadline for the elimination of organotin compounds from ships' hulls or its effective containment on hulls.
At no time has there been any risk from wearing a NIKE sport shirt, where the risk is related to the health analyzed contaminations of organotin compounds.
Many organotin compounds, including triethyltin bromide, tributyltin methacrylate, bis(tributyltin)oxide, tributyltin chloride, triphenyltin acetate, and triphenyltin hydroxide, are also among the most potent compounds identified in the present study.
The production worldwide of organotin compounds was some 35 000 tons in 1980 of which 8 000 tons were triorganotin compounds for biocidal use; 3 000 tons were produced for antifouling paints, 1 000 tons for wood preservatives, 3 000 tons for agrochemicals and 1 000 tons for disinfectants.
The best such catalysts are the organotin compounds.
Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates.
Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway.