organotin

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Related to Organotin compound: Stannanes

organotin

Any tin-based organic compound in wide use for marine anti-fouling paints, wood catalysts, plasticisers, slimicides, in industrial water systems and as fungicides. Human exposure results from contaminated seafood, agricultural products and drinking water. Blood levels of organotins may be high enough to act on retinoid X receptors and PPAR gamma, upregulating the adipogenic signalling pathway, which explains organotins’ obesogenic effects.
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The mechanism of the neurotoxicity and underlying selective vulnerability of trimethyltin have not been fully elucidated it has been proposed that mitochondrial targeting of the organotin compounds leads to a change in local microenvironment in which TMT interacts with the protein Stannin, compromising the integrity of the mitochondrial membrane and initiating apoptosis (Billingsley et at.
The concentrations of all organotin compounds were clearly higher (t-test, P < 0.
A concentration of 2 mM DTT, added simultaneously with 5 [micro]M of the corresponding organotin compound, restored 70-80% of 11[beta]-HSD2 activity.
Similar variation occurs in sensitization tests, and the database should be regarded as inadequate to draw firm conclusions; however, a number of organotin compounds have shown strong sensitization in some tests, and it would be precautionary to regard the group as sensitizing.
The industry's concern is heightened by the treaty's looming January 2008 deadline for the elimination of organotin compounds from ships' hulls or its effective containment on hulls, NPCA said.
Brominated flame retardants, which are thought to interfere with the hormone systems vital to growth, and organotin compounds, considered harmful to the immune system, were also found in every sample.
Chapter 11 Organotin Compounds Analysis (Maw-Rong Lee and Chung-Yu Chen).
When the analyte is first and foremost parameter of the WFD and the surface water regulation (eg, organotin compounds, pesticides, biocid
Presently, the most effective approach for prevention of marine biofouling is the use of antifouling paints and coatings which function through the release of toxic ingredients such as cuprous oxide and organotin compounds.
Other topics of the ten papers include optimizing the photoreactivity of chemical compounds, multiple-bonded and aromatic organotin compounds, ligand effects on 3-membered hydrocopper rings, and magnetostructural D-correlation for zero field splitting in nickel(II) complexes.