organotin

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Related to Organotin compound: Stannanes

organotin

Any tin-based organic compound in wide use for marine anti-fouling paints, wood catalysts, plasticisers, slimicides, in industrial water systems and as fungicides. Human exposure results from contaminated seafood, agricultural products and drinking water. Blood levels of organotins may be high enough to act on retinoid X receptors and PPAR gamma, upregulating the adipogenic signalling pathway, which explains organotins’ obesogenic effects.
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2007), it is expected that the sediment will have a high concentration of this organotin compound, of ancient or recent origin.
The mechanism of the neurotoxicity and underlying selective vulnerability of trimethyltin have not been fully elucidated it has been proposed that mitochondrial targeting of the organotin compounds leads to a change in local microenvironment in which TMT interacts with the protein Stannin, compromising the integrity of the mitochondrial membrane and initiating apoptosis (Billingsley et at.
The concentrations of all organotin compounds were clearly higher (t-test, P < 0.
A concentration of 2 mM DTT, added simultaneously with 5 [micro]M of the corresponding organotin compound, restored 70-80% of 11[beta]-HSD2 activity.
Moreover, in general, the biological activity of organotin compounds appears to be greatly influenced by the structure of the molecule and likely by the nuclearity of the complexes [16, 17].
Organotin compounds are highly lipophilic and readily penetrate the blood-brain barrier to enter the brain (Kotake 2012).
Further, concentrations of organotin compounds are high in ports and shipyards.
For their review, researchers from the University of Portsmouth and the Centre of Environment, Fisheries and Aquaculture Science (Cefas) looked at the monitoring and analysis techniques available to detect organotin compounds like TBT in the environment.
European Commission Decision 2009/425/EC, which includes restrictions on the use of dibutyltin, dioctyltin, and tri-substituted organotin compounds, was incorporated into ANNEX XVII of REACH through regulation (EU) 276/2010.
caused by organotin compounds used in anti-fouling systems.
Organotin compounds such dibutyltin dilaurate are widely used as catalysts.