transplant rejection

(redirected from Organ rejection)

transplant rejection

Graft rejection, organ rejection, tissue rejection Immunology The constellation of host immune responses evoked when an allograft tissue is transplanted into a recipient; rejection phenomena may be minimized by optimal matching of MHC antigens and ABO blood groups and ameliorated with immunosuppressants–eg, cyclosporin, tacrolimus, rapamycin Exceptions of TR Corneal transplants, identical twins. See Graft-versus-host disease, HLA, MHC, Tissue typing.


1. an organ or tissue taken from the body and grafted into another area of the same individual or another individual.
2. to transfer tissue from one part to another or from one individual to another.

ovum transplant
see ovum transplant.
transplant rejection
References in periodicals archive ?
Biopharmaceutical company Veloxis Pharmaceuticals A/S said on Wednesday that it has filed its supplemental New Drug Application (sNDA) with the US Food & Drug Administration (FDA) for ENVARSUS XR (tacrolimus extended-release tablets) for the prophylaxis of organ rejection in kidney transplant patients.
Organ rejection is a serious problem that arises when the recipient's body identifies the new organ as a foreign material.
This could eliminate the challenges of organ rejection and long donor waiting lists that plague existing organ transplant methods.
The topic of adherence and taking medications as prescribed is especially critical in transplantation, as recipients must take lifelong immunosuppressive medications to prevent possible organ rejection.
ISLAMABAD -- A new pre-operative drug therapy to reduce antibodies in kidney patients may increase their chance for kidney transplantation and decrease the likelihood of organ rejection, said a new study.
Veloxis Pharmaceuticals A/S, Horsholm, Denmark announced the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending the granting of a marketing authorization for Envarsus for the prevention of organ rejection in adult transplant patients in the European Union (EU).
The xenotransplanted muscle tissue, transplanted by a team lead by the UCL Institute of Child Health, London, retained its biochemical properties and also triggered anti-inflammatory and immunosuppressive response, preventing the typical immune system 'attack' that can lead to organ rejection.
A simple test might reveal whether a kidney transplant recipient is at imminent risk of organ rejection.
This is good news since it moves us from the current one-size-fits-all treatment model to a much more personalized plan," he says, noting that too little immunosuppression leads to organ rejection and too much can lead to infection or even cancer," the researcher said.
However, like all cells, they are susceptible to being killed by the body's complement system, a part of the immune system involved in inflammation and organ rejection.
It is likely they will contract HIV and treatment will be complicated as they have to take drugs to avoid organ rejection.
Doctors say Jensen was an ideal and rare candidate for the larynx, or voicebox, transplant, because after receiving a kidney and pancreas transplant in 2006, she was already taking a regimen of medications to guard against organ rejection.