orexins


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Related to orexins: suvorexant

orexins

(o-rek-sinz)
Neuropeptides produced by the hypothalamus that influence sleep and wakefulness.
Synonym: hypocretins; hypocretin
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Moreover, a recent review reported that orexins may be considered a treatment target for the abuse of alcohol and other substances, such as cocaine.
Neurons located in the lateral hypothalamic (LH) area, the dorsomedial nucleus of the hypothalamus and perifornical hypothalamus produce orexins (OX-A and OX-B), also named hypocretins.
Examining the role of endogenous orexins in hypothalamus-pituitary-adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat.
Verkhratsky, "Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ," The Journal of Neuroscience, vol.
(1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
(Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") announced today that it has presented data from a Phase II clinical study (Study 201) on its in-house-developed investigational dual orexin receptor antagonist (DORA) E2006 in patients with insomnia disorder at the 53rd American College of Neuropsychopharmacology (ACNP) Annual Meeting held from December 7 through 11, 2014, in Phoenix, Arizona in the United States.
Since their discovery, orexins have been the focus of intense research, and there are substantial data implicating the functional effects of orexins in other systems.
Hypothalamic NPY/AgRP neuronal activity, but not MCH or orexin neurons, significantly increased.
Ghrelin and orexins were determined in plasma by EIA (Phoenix Pharmaceuticals Inc.
At a mechanistic level, important developments in recent years include the identification of novel neuroendocrine factors in the control of appetite (such as cocaine- and amphetamine-regulated transcript, the orexins, the endocannabinoids) and the discovery of new peripheral signals (such as leptin, ghrelin).