A non-neoplastic light microscopic finding which corresponds to 'pumpkin orange' parakeratosis in pap-stained preparations of squamous cells. While orangeophilia may be seen in poorly-differentiated squamous cell carcinoma (SCC) of the head & neck and possibly the uterine cervix, it is not a neoplastic change
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The cellular reactions associated with Candida are well described and include nuclear enlargement, hyperchromasia, cytoplasmic orangeophilia, and perinuclear halos.