Orangeophilia

A non-neoplastic light microscopic finding which corresponds to 'pumpkin orange' parakeratosis in pap-stained preparations of squamous cells. While orangeophilia may be seen in poorly-differentiated squamous cell carcinoma (SCC) of the head & neck and possibly the uterine cervix, it is not a neoplastic change
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2) Positive for malignant cells [3, 4]: The smears are highly cellular with following cellular characteristics: (a) Ill-defined cell border; (b) High cellular atypia; (c) High nuclear atypia; (d) Enlarged nuclei with high N: C ratio; (e) Condensation of nuclear chromatin forming strands, coarse clumps and dense peripheral nuclear outlines; (f) Densely packed hyperchromatic nuclei in compact groups with no visible cell outline; (g) Multiple and enlarged nucleoli; (h) Multinucleated giant cells; (i) Tendency towards spherical shape; (j) Cytoplasmic orangeophilia with hyperchromatic irregular nucleus; (k) Keratinised pearls of malignant cells are frequently seen; (l) The background is necrotic with blood and numerous leukocytes.
The cellular reactions associated with Candida are well described and include nuclear enlargement, hyperchromasia, cytoplasmic orangeophilia, and perinuclear halos.