bioavailability

(redirected from Oral bioavailability)
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bioavailability

 [bi″o-ah-vāl″ah-bil´ĭ-te]
the degree to which a drug or other substance becomes available to the target tissue after administration.

bi·o·a·vail·a·bil·i·ty

(bī'ō-ă-vāl'ă-bil'i-tē),
The physiologic availability of a given amount of a drug, as distinct from its chemical potency; proportion of the administered dose that is absorbed into the bloodstream.

bioavailability

/bio·avail·a·bil·i·ty/ (bi″o-ah-vāl″ah-bil´ĭ-te) the degree to which a drug or other substance becomes available to the target tissue after administration.

bioavailability

(bī′ō-ə-vā′lə-bĭl′ĭ-tē)
n.
The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration.

bi′o·a·vail′a·ble (-lə-bəl) adj.

bioavailability

[-əvā′libil′itē]
Etymology: Gk, bios + ME, availen, to serve
the degree of activity or amount of an administered drug or other substance that becomes available for activity in the target tissue.

bioavailability

The rate and extent to which a drug is available to serve as a substrate, bind to a specific molecule or participate in biochemical reactions in a target tissue after administration. For oral agents, bioavailability reflects the rate and extent of GI tract absorption.

Bioavailability depends on the pI (isoelectric point), the pH of a solution in which the solute does not migrate (ionic form), presence of side chains or the conformation of the epitope. Bioavailability is affected by the route of administration, rate of metabolism, lipid solubility and binding proteins. It is usually < 100% due to degradation or alteration before reaching the target tissue.

bioavailability

Clinical pharmacology The degree to which a drug is available to a target tissue after administration which, for oral drugs, reflects the rate and extent of GI tract absorption; BA is the in vivo presence of a substance in a form that allows it to be metabolized, serve as a substrate, bind a specific molecule, or participate in biochemical reactions. See Oral bioavailability.

bi·o·a·vail·a·bil·i·ty

(bī'ō-ă-vāl'ă-bil'i-tē)
The physiologic availability of a given amount of a drug, as distinct from its chemical potency; proportion of the administered dose that becomes available to exert a pharmacologic effect into the bloodstream.

bioavailability

The amount of a drug that reaches the blood regardless of how it is given. After intravenous injection bioavailability is 100%, but the bioavailability of drugs given by mouth is often much less, because many drugs are broken down by the digestive enzymes and many are poorly absorbed.

Bioavailability

A measure of the amount of drug that is actually absorbed from a given dose.
Mentioned in: Antiretroviral Drugs

bioavailability

physiological availability of a given amount of drug

bioavailability (bīˈ·ō··vālˈ··bilˑ·i·tē),

n the amount of or rate at which a substance or drug is accessible to the body.

bi·o·a·vail·a·bil·i·ty

(bī'ō-ă-vāl'ă-bil'i-tē)
Physiologic availability of a given amount of a drug, as distinct from its chemical potency.

bioavailability

the degree to which a drug or other substance becomes available to the target tissue after administration.
References in periodicals archive ?
Recent advancements with novel, innovative formulation technology offer dramatically enhanced oral bioavailability with cyanocobalamin.
Presentation: "Enhancing Oral Bioavailability using Amorphous Molecular Dispersions: Industry Implications and Approaches for Successful cGMP Formulation Development"
Pharmaceuticals, VIRUN[R] utilize patented technologies to improve the pharmacokinetics (delivery) and dynamics (efficacy) of peptides and compounds that have poor oral bioavailability or over-all functionality.
Although these compounds have limited utility because of kidney toxicity and lack of oral bioavailability, batyl alcohol analogs of these compounds show favorable activity and resistance profiles and will presumably be tested further.
Aphios is enhancing the oral bioavailability of therapeutic proteins by encapsulating protein macromolecules and nanoparticles in biodegradable polymer nanospheres," says Dr.
The goal of the partnership is to commercialize proprietary formulations of nature-identical synthetic astaxanthin products with pharmaceutical-grade purity that will provide improved oral bioavailability compared with other astaxanthin products on the market.
Published scientific studies report CBD oral bioavailability in the range of between 10 - 20%.
Through its' endeavors, VIRUN has developed technologies to achieve extraordinary oral bioavailability of naive peptides, for example insulin at greater than 61% compared to i.
Further, improved oral bioavailability significantly above that of crystalline drug has been demonstrated in 17 clinical trials conducted by Pfizer, including one Phase III trial.
Oral bioavailability of DCA was 0-13% in naive and 14-75% in GST[zeta]-depleted rats.
patents related to its pioneering efforts to improve the oral bioavailability of low-solubility drugs.
As reported in the prior Phase 1 study, oral CR845 demonstrated a mean oral bioavailability of 16% across all groups under fasting conditions, with peak and total exposures proportional to each dose.