codeine phosphate

(redirected from Opioid Agonist)

co·deine phos·phate

a water-soluble salt of codeine often used in the pharmaceutical preparation of liquid medications containing codeine.

codeine phosphate

an opioid analgesic and antitussive.
indications It is prescribed to suppress cough and to relieve mild to moderate pain.
contraindication Known hypersensitivity to opiates is the only contraindication.
adverse effects Among the more serious adverse reactions are depression of the central nervous system, paradoxic excitement, and drug dependence.

codeine phosphate

The phosphate of the alkaloid codeine; used because of its free solubility in water.
See also: codeine

codeine phosphate

narcotic opioid analgesic derived from morphine, used to control pain; also formulated with paracetamol (e.g. 30 mg codeine phosphate and 500 mg paracetamol tablets; Table 1); regular use predisposes to constipation; overdose suppresses both respiration and cough reflex, and can cause death
Table 1: Analgesic codeine preparations
AgentConstituents
Co-codamol(8/500) 8 mg codeine phosphate; 500 mg paracetamol
(15/500) 15 mg codeine phosphate; 500 mg paracetamol
(30/500) 30 mg codeine phosphate; 500 mg paracetamol
Co-dydramol(10/500) 10 mg dihydrocodeine tartrate; 500 mg paracetamol
Co-proxamol(32.5/325) 32.5 mg dextropropoxyphene hydrochloride; 325 mg paracetamol

Note: co-proxamol withdrawn in UK, due to adverse links to heart failure and respiratory depression

References in periodicals archive ?
Oxycodone Hydrochloride Oral Solution 5mg/5mL is an opioid agonist indicated for the management of moderate to severe pain where the use of an opioid analgesic is appropriate.
These adverse effects are attributed to the opioid agonist effects on central opioid receptorscausing dependence, tolerance, sedation, and respiratory depression.
The study among 552 young-adult injecting drug users, who were followed for 680 person-years, documented 171 cases of HCV infection, but found the rate of infection was significantly lower among those on opioid agonist maintenance therapy, compared with those on non--opioid agonist treatment or opioid agonist detoxification therapy
OST consists of the medically supervised daily consumption of an individualised dose of long-acting oral or sublingual opioid agonist or partial agonist; this is a substitute for the illicit usually smoked or injected opioid, thereby preventing withdrawal symptoms and cravings.
They make recommendations concerning opioid agonist maintenance treatment, methadone compared to buprehorphine for opioid agonist maintenance treatment, the use of methadone and of buprenorphine in maintenance treatment, treatment for withdrawal and prevention of relapse, and the use of naltrexone to prevent relapse.
Though various treatments, particularly opioid agonist treatment for withdrawal and maintenance, and antagonists for maintenance have been available, only a few health professionals are aware of their appropriate use.
Substitution detoxification involves the use of either a full or partial opioid agonist, which is prescribed at an individualised dose that alleviates withdrawal symptoms without causing intoxication.
Adolor and Pfizer Inc (NYSE:PFE) are collaborating on the worldwide development and commercialization of two novel Delta opioid agonist compounds, ADL5859 and ADL5747, for the treatment of pain.
BTG (LSE: BGC), the medical innovations company, has acquired an opioid agonist for the control of post-operative pain from CLL Pharma, a drug development company based in Nice, France, in return for undisclosed milestone and royalty payments.
Methadone is an opioid agonist, meaning that it activates opioid receptors in the brain to reduce pain and create euphoria.
Unfortunately, most inmates are not exposed to treatment while incarcerated (Inciardi, McBride and Surratt, 1998; Smith-Rohrberg, Bruce and Altice, 2004); furthermore, effective opioid agonist treatment (with methadone or buprenorphine) is rarely offered in U.
This compound has been shown to be a potent kappa opioid agonist in vitro and in vivo.