Ondine's curse


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Ondine's curse

 [on´dēnz]
a condition in which patients have lost autonomic control of respiration and become apneic upon falling asleep; it is due to lesions or surgery of the high spinal cord or brainstem; named after Ondine, a water nymph in Greek mythology who caused a mortal who loved her to sleep forever.
A popular term for
(1) Primary alveolar (congenital central) hypoventilation (central apnoea)
(2) Sleep apnoea syndrome

On·dine's curse

(on-dēn' kŭrs)
Idiopathic central alveolar hypoventilation in which involuntary control of respiration is depressed, but voluntary control of ventilation is not impaired.
[Ondine, char. in play by J. Giraudoux, based on Undine, Ger. myth. char.]
References in periodicals archive ?
Congenital central hypoventilation syndrome (CCHS), also known as Ondine's curse, is a rare disease characterized by autonomic respiratory dysfunction without any pulmonary, cardiac, or neuromuscular disorder (1).
There is also a report of an infant being borne with Ondine's curse (central hypoventilation syndrome) from a mother with typical presentation of IH in her 8th month of pregnancy [17].
Smith, "Ondine's curse in a woman with Leber's hereditary optic neuropathy," Journal of Neurology, Neurosurgery & Psychiatry, vol.
The term "Ondine's curse" was first used by Severinhaus and Mitchell [1] to describe patients who were able to breathe voluntarily after undergoing bilateral spinothalamic tract cordotomies but subsequently became apneic during sleep.
We even tap the myths to describe body parts as in the Achilles tendon, and rare disorders such as Ondine's Curse (congenital central hypoventilation syndrome), a condition in which one lacks the autonomic control for breathing (you must remember to breathe, or die).
It is also known as Ondine's curse, named after an ancient myth where a water nymph puts a spell on her cheating husband to stay awake forever.
Congenital central hypoventilation syndrome (CCHS), known as the literary misnomer "Ondine's curse" (Mendelian Inheritance in Man number: 209880), is a rare disorder of respiratory control with related autonomic nervous system deregulation/ dysfunction.
"This basic science information has to be used rapidly in order to determine whether glial dysfunction contributes to serious disorders of central control of breathing underlying Sudden Infant Death Syndrome and/or congenital central hypoventilation syndrome (Ondine's curse).
Ondine's Curse may also be possibly related to Hirschsprung's Disease, but the diagnosis of CCHS is so rare that it has an estimated prevalence of one case per 200,000 live births, with only about 300 children living worldwide with CCHS diagnosis.
His breathing difficulties are caused by a syndrome called Ondine's Curse, when the nervous system fails to control breathing while the sufferer is asleep.