Chemotherapy was initiated with rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin
, and prednisone (R-CHOP), and the patient was given intrathecal methotrexate once for CNS chemoprophylaxis.
According to the new report entitled Emerging Therapies Will Be Adjuncts in this Niche Market: An Acute Lymphoblastic Leukemia Study, the combination use of Rituxan and the standard chemotherapy regimen hyper-CVAD (a treatment regimen that includes Bristol-Myers Squibb's Cytoxan, Baxter/Shionogi Seiyaku's Endoxan, generics; Eli Lily's Oncovin
, generics; Bedford Labs' Adriamycin, Pfizer's Ariblastine/Adriacin, generics; Merck's Decadron, generics; Stada Pharmaceuticals' Rheumatrex, generics; Pfizer's Cytosar-U/Aracytine, Nippon Shinyaku's Cylocide, generics; and prednisone) shows the most promise and achieves the highest overall clinical rating among the emerging therapies.
Treatment for stage IVB Hodgkin lymphoma was begun, consisting of cytoxan, oncovin
, prednisone, and procarbazine alternating with adriamycin, bleomycin, and vinblastine.
R-EPOCH: rituximab plus etoposide (Bristol-Myers Squibb's Etopophos/Vepesid, Pfizer/Nippon Kayaku's Lastet, Baxter's Celltop, generics), prednisone (Sanofi's Cortancyl, Merck KGaA's Decortin, generics), vincristine (Genus Pharmaceuticals/Nippon Kayaku's Oncovin
, generics), cyclophosphamide (Bristol-Myers Squibb's Cytoxan, Pfizer's Cyclophospham, generics) and doxorubicin (Pfizer's Adriamycin/Adriblastine/Adriacin, generics).
There are currently five off-label drugs such as Oncovin
(vincristine), Adriamycin (doxorubicin), Cytoxan/Neosar (cyclophosphamide), Ifex (ifosfamide) and Vepesid (etoposide) which have been moderately effective in the treatment of Ewing's sarcoma.
The treatment can be administered by IV, IP or orally and it has been shown to enhance the performance of at least six different chemotherapeutic drugs (adriamycin, asparaginase, cyclophosphamide, 5-fluorouracil, oncovin
Combined chemotherapy consisting of 6 courses of standard CHOP (cyclophosphamide, hydroxydaunomycin, Oncovin
[vincristine], and prednisone) and additional 25 sessions of 45 Gy of fractionated radiation treatment were administered.