The standard therapy regimen for DLBCL is immnunochemotherapy, a combination of rituximab and cyclophosphamide, hydroxydaunomycin,
oncovin, prednisolone (R-CHOP) [5].
R-CHOP regimen is the standard treatment for follicular lymphoma and includes rituximab plus cyclophosphamide, hydroxydaunorubicin,
oncovin (vincristine), and prednisone or prednisolone.
* cyclophosphamide (Cytoxan), doxorubicin (Adriamycin) and vincristine (
Oncovin)
Various treatment modalities of Non-Hodgkin's Lymphoma include radiotherapy, chemotherapy and surgery in various combinations.1 However standard modality has been chemotherapy and the regimen includes cyclophosphamide, doxorubicin,
oncovin and predinsilone(CHOP).4 Radiotherapy in the range of 2400-5600cGy (35-40Gy) delivered in 180cGy daily fractions has proven successful in early cases.8 Radio immunotherapy has been employed as a new therapy for relapse cases.
*
Oncovin (vincristine), which prevents cells from duplicating by binding to the protein tubulin
Chemotherapy was modified; eight patients received the agents
oncovin, cyclophosphamide, and cosmogen in kg dosing with 50% reduction, four patients received full kg dosing, and 5 patients received 1200-1800 mg/[m.sup.2] without modifications according to tolerance.
Chemotherapy was administered after the operation: CHOP (500 mg/m[sup.2] cyclophosphamide and 30-50 mg/m[sup.2] adriamycin and l-2 mg
oncovin intravenously infused on day 1; and 40 mg prednisone taken orally on days 1-5, with an interval of 3 weeks between two courses of treatment).
Five of the patients who were diagnosed as Hodgkin lymphoma were treated with adriablastine, belomycine, vinblastine, dacabazine, six were treated with cyclophosphamide,
oncovin, procarbazine and prednisolone and six were treated with successive adriablastine, bleomycine, vinblastin, dacarbazine-cyclophosphmide, vincristin, procarbazine and prednisolone.
A acao do decanoato de nandrolona (Deca-durabolin) sobre parametros hematologicos e proteina total plasmatica de ratos (Rattus rattus) com depressao medular induzida apos administracao de sulfato de vincristina (
Oncovin).
Non-toxic sensitization of cancer chemotherapy by combined vitamin C and K3 pretreatment in a mouse tumor resistant to
Oncovin. Anticancer Res.
and vincristine (
Oncovin) from Cantharanthus roseus G.
The drug that started it all, Mustargen, became a key element in the revolutionary MOPP (Mustargen,
Oncovin, procarbazine, and prednisone) combination chemotherapy regimen pioneered by Dr.