The standard therapy regimen for DLBCL is immnunochemotherapy, a combination of rituximab and cyclophosphamide, hydroxydaunomycin, oncovin
, prednisolone (R-CHOP) .
R-CHOP regimen is the standard treatment for follicular lymphoma and includes rituximab plus cyclophosphamide, hydroxydaunorubicin, oncovin
(vincristine), and prednisone or prednisolone.
* cyclophosphamide (Cytoxan), doxorubicin (Adriamycin) and vincristine (Oncovin
Various treatment modalities of Non-Hodgkin's Lymphoma include radiotherapy, chemotherapy and surgery in various combinations.1 However standard modality has been chemotherapy and the regimen includes cyclophosphamide, doxorubicin, oncovin
and predinsilone(CHOP).4 Radiotherapy in the range of 2400-5600cGy (35-40Gy) delivered in 180cGy daily fractions has proven successful in early cases.8 Radio immunotherapy has been employed as a new therapy for relapse cases.
(vincristine), which prevents cells from duplicating by binding to the protein tubulin
Chemotherapy was modified; eight patients received the agents oncovin
, cyclophosphamide, and cosmogen in kg dosing with 50% reduction, four patients received full kg dosing, and 5 patients received 1200-1800 mg/[m.sup.2] without modifications according to tolerance.
Chemotherapy was administered after the operation: CHOP (500 mg/m[sup.2] cyclophosphamide and 30-50 mg/m[sup.2] adriamycin and l-2 mg oncovin
intravenously infused on day 1; and 40 mg prednisone taken orally on days 1-5, with an interval of 3 weeks between two courses of treatment).
Five of the patients who were diagnosed as Hodgkin lymphoma were treated with adriablastine, belomycine, vinblastine, dacabazine, six were treated with cyclophosphamide, oncovin
, procarbazine and prednisolone and six were treated with successive adriablastine, bleomycine, vinblastin, dacarbazine-cyclophosphmide, vincristin, procarbazine and prednisolone.
A acao do decanoato de nandrolona (Deca-durabolin) sobre parametros hematologicos e proteina total plasmatica de ratos (Rattus rattus) com depressao medular induzida apos administracao de sulfato de vincristina (Oncovin
Non-toxic sensitization of cancer chemotherapy by combined vitamin C and K3 pretreatment in a mouse tumor resistant to Oncovin
. Anticancer Res.
and vincristine (Oncovin
) from Cantharanthus roseus G.
The drug that started it all, Mustargen, became a key element in the revolutionary MOPP (Mustargen, Oncovin
, procarbazine, and prednisone) combination chemotherapy regimen pioneered by Dr.