oncostatin M

(redirected from Oncostatin)

on·co·stat·in M

(ong'kō-stat'in), [MIM*165095]
A cytokine from macrophages, T cells, and some marrow and tumor cells, possessing various differentiation (in macrophages), cell proliferation (in hemopoietic precursors and some tumor types), and maturation (in fetal hepatocytes) effects.
[onco- + -stat + -in]
References in periodicals archive ?
This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.
Measurement of gp130 cytokines oncostatin M and IL-6 in gingival crevicular fluid of patients with chronic periodontitis.
Our group recently showed that mice lacking the P2X7 receptor (a P2 purinoceptor specific for ATP) on their mast cells were resistant to 2,4,6-trinitrobenzene sulfonic acid--induced intestinal inflammation, whereas the activation of mast cells induced by the interaction between ATP and P2X7 purinoceptor elicited the production of inflammatory cytokines such as IL-6, tumor necrosis factor [alpha], and oncostatin M.
Oncostatin M induced alpha1-antitrypsin (AAT) gene expression in Hep G2 cells is mediated by a 3' enhancer.
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction.
Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: roles of tumor necrosis factor-alpha and oncostatin M derived from macrophages.
Bet[alpha]-adrenergic receptor agonists induce the release of granulocyte chemotactic protein2, oncostatin M, and vascular endothelial growth factor from macrophages.
Digna's therapeutic areas include P144, P17, IFN alfa 5, cardiotrophin -1 (CT-1), V-phorphyria, IFN +CT1 + oncostatin and MTA.
Thomas Braun's research group at the Max Planck Institute for Heart and Lung Research in Bad Nauheim initially noticed the high concentration of oncostatin M in tissue samples from the hearts of patients suffering from myocardial infarction.
The scientists initially noticed the high concentration of oncostatin M in tissue samples from the hearts of patients suffering from myocardial infarction, and it is already known that this protein is responsible for the dedifferentiation of different cell types.