The trial is designed to identify chronic pruritic conditions where signaling through oncostatin
M receptor beta (OSMR) may be playing a role and to investigate the efficacy, safety and tolerability of KPL-716 in reducing the moderate-to-severe pruritus experienced by these subjects.
Kiniksa announced interim repeated-single-dose Phase 1b clinical data for KPL-716, an investigational fully-human monoclonal antibody that targets oncostatin
M receptor beta, or OSMRbeta.
Furthermore, it is known that IL-6 acts synergistically with IL-1 and oncostatin
M to upregulate MMP-1 and MMP-13 in bovine and human cartilage explant cultures (POREE et al., 2008).
M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members.
Human upcyte[R] hepatocytes (1) are primary human hepatocytes derived by transducing E6 and E7 proteins of human papillomaviruses, which release hepatocytes from cell cycle arrest and allow their proliferation in response to oncostatin
M (OSM), a member of the interleukin-6 (IL-6) superfamily involved in liver regeneration.
Liu, "Janus kinase activation by cytokine oncostatin
M decreases PCSK9 expression in liver cells," Journal of Lipid Research, vol.
(2) Hepatocyte (3) ADMEM (4) 2% FBS (5) 10 ng/ml of oncostatin
M (6) 10 nmol/L dexamethasone (7) 1% insulin transferrin- selenium 4.
M and interleukin-31: cytokines, receptors, signal transduction and physiology," Cytokine & Growth Factor Reviews, vol.
Dillon, "IL-31 receptor (IL-31RA) knockout mice exhibit elevated responsiveness to oncostatin
M," Journal of Immunology, vol.
Neutrophils, as a type of inflammatory cells, are considered to be involved in different steps of tumor development through the production of a variety of cytokines, such as oncostatin
M, hepatocyte growth factor, and transforming growth factor- (TGF-) [beta] .
It is worth noting that addition of oncostatin
M to induce further maturation of hepatocytelike cells showed no effect on the parameters measured in the current study (data not shown).
Measurement of gp130 cytokines oncostatin
M and IL-6 in gingival crevicular fluid of patients with chronic periodontitis.