RUNX2(redirected from Oncogene AML-3)
RUNX2A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
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