Two other agents in this class, balsalazide (Colazal) and olsalazine
(Dipentum), are broken down in the colon to 5-ASA.
Three medicines are used for treating an acute attack: Aminosalicylates (such as balsalazide, mesalazine, olsalazine
, sulfasalazine), Corticosteroids (budesonide, hydrocortisone, prednisolone) and Immunosuppressants (azathioprine, ciclosporin, mercaptopurine) Rest is important during an attack to allow healing to take place.
and 6-mercaptopurine-related bone marrow suppression: a possible drug-drug interaction.
Active UC should be treated initially with systemic aminosalicylate drugs (such as sulfasalazine, olsalazine
, balsalazide, and mesalamine) or with corticosteroids.
In vitro kinetic studies with recombinant human TPMT demonstrated that sulfasalazine, 5-aminosalicylic acid, balsalazide, and olsalazine
(3-5) inhibit the enzyme activity in a noncompetitive manner.