The announcement is especially interesting to researchers in the Synthetic Biology and Diagnostic sectors, which require large volumes of both genes and oligonucleotides
18.104.22.168 Increasing Awareness About Advancements in Oligonucleotides
to Drive the Market
"Additionally, the opening of the new oligonucleotide
API development center furthers our commitment to enhancing our service offerings and responsiveness to our customers' needs."
Focused presentations on oligonucleotide
therapies, opportunities and challenges in drug developments, and securing oligonucleotide
Wave is developing oligonucleotide
therapeutics to target diseases that have been historically difficult to treat with small molecules or biologics.
(21) For example, random oligonucleotides
are often synthesized with "wings" attached at either end, consisting of a known sequence.
Unlike existing antisense therapies that target RNA, an antigene drug is a triplex-forming oligonucleotide
that recognizes and attaches directly to a specific DNA sequence.
While traditional methods require eight steps and can take two hours, the Clarity OTX extraction kits isolate oligonucleotide
therapeutics and their metabolites in 15 minutes.
Editors Moretti and Rizzo (no affiliations listed) have collected research in the field on the use of oligonucleotides
for detecting complementary DNA and RNA such as in DNA microarrays and the synthesis of artificial genes.
All regions with a minimum of 5 consecutive oligonucleotides
indicating significant copy number variation were investigated further; common copy number variants were assessed by position comparison with copy number variation databases and by comparison with parental CGH patterns, when available.
Methods: Nuclear extracts from hematopoietic and non-hematopoietic cells are incubated with labeled double stranded oligonucleotides
from 50-200 bp in length in EMSA binding buffer.
Based in the Netherlands, the business provides oligonucleotides
. Financial details were not disclosed.