grape seed extract

(redirected from Oligomeric proanthocyanidins)

grape seed extract

(grayp seed ex-trakt) ,

Vitis vinifera

(trade name),

Vitis coignetiae

(trade name),

Oligomeric Proanthocyanidins (OPCs)

(trade name)


Therapeutic: cardioprotective agents
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.


Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.

Therapeutic effects

Reduced risk of coronary disease.
Decreased skin and vasculature breakdown.


Absorption: Unknown.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile



Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.
Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.

Adverse Reactions/Side Effects


  • hypertension

Central nervous system

  • dizziness
  • headache


  • dry skin

Ear, Eye, Nose, Throat

  • sore throat
  • cough


  • nausea
  • diarrhea


  • ↑ risk of bleeding


May ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.
Oral (Adults) 75–300 mg daily.


Tablets :

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance (Indications)


  • Administer as directed. Doses may vary.

Patient/Family Teaching

  • Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected.

Evaluation/Desired Outcomes

  • Decrease in cholesterol.
  • Decrease in BP.

grape seed extract

Abbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse.
See also: extract
References in periodicals archive ?
Greenblatt and Winnie Lee, RN, write about optimizing attention-deficit hyperactivity disorder (ADHD) treatment with oligomeric proanthocyanidins (OPCs).
Combining critical heart nutrients with a uniquely standardized grape seed extract with oligomeric proanthocyanidins (OPCs), the formulation is designed to provide significant cardiovascular benefits, the company said.
Elouise Bauskis said: "Grape seed extract, too, contains oligomeric proanthocyanidins which are highly antioxidant, providing great protection to cells as well as strengthening cell walls.
They have oligomeric proanthocyanidins, a class of flavonoid complexes that, according to some studies, helps stabilize and maintain collagen.
Grape Seed is also one of the richest sources of oligomeric proanthocyanidins (better known as OPC).
Oligonol is produced by the oligomerization of polyphenol polymers, typically proanthocyanidins, thus oligonol delivers higher levels of the oligomeric proanthocyanidins compared to fruits and plant sources that contain mostly large molecular weight proanthocyanidins.
These include oligomeric proanthocyanidins (OPCs) and other bioflavonoids like catechin, epicatechin, phenolic fruit acids, and taxifolin.
Grape Seed is an excellent source of many powerful antioxidants such as oligomeric proanthocyanidins (OPCs), vitamin E, flavonoids, linoleic acid, and resveratrol.
They have a high concentration of vitamin E, flavonoids, linoleic acid and oligomeric proanthocyanidins.
Grape seed extract is a naturally occurring plant substance that contains a concentrated source of antioxidant nutrients known as oligomeric proanthocyanidins more commonly known as OPCs.
Vitamin E, flavonoids, linoleic acid and compounds called procyanidins (also known as pycnogenols, and oligomeric proanthocyanidins or OPCs) are highly concentrated in grape seeds.
OPC stands for oligomeric proanthocyanidins, which means short chains of what comes before the anthocyanins.