estrogen receptor

(redirected from Oestrogen receptor)

receptor

 [re-sep´tor]
1. a molecule on the cell surface (cell-surface or membrane receptor) or within a cell, usually in its nucleus (nuclear receptor) that recognizes and binds with specific molecules, producing some effect in the cell; e.g., the cell-surface receptors of immunocompetent cells that recognize antigens, complement components, or lymphokines; or those of neurons and target organs that recognize neurotransmitters or hormones.
2. a sensory nerve ending that responds to various stimuli.
General sense receptors. (From Applegate, 2000.)
α-r's (α-adrenergic r's) alpha-adrenergic receptors.
adrenergic r's receptors for epinephrine or norepinephrine, such as those on effector organs innervated by postganglionic adrenergic fibers of the sympathetic nervous system. There are two types, alpha-adrenergic receptors and beta-adrenergic receptors.
alpha r's (alpha-adrenergic r's) adrenergic receptors found in cardiac muscle and vascular smooth muscle; they are stimulated by norepinephrine and blocked by agents such as phenoxybenzamine. They are subdivided into two types: α1, found in smooth muscle, heart, and liver, with effects including vasoconstriction, intestinal relaxation, uterine contraction and pupillary dilation, and α2, found in platelets, vascular smooth muscle, nerve termini, and pancreatic islets, with effects including platelet aggregation, vasoconstriction, and inhibition of norepinephrine release and of insulin secretion. Called also α-receptors and α-adrenergic receptors.
β-r's (β-adrenergic r's) beta-adrenergic receptors.
B cell antigen r's monomeric IgM, IgD, and (on memory cells only) IgG that is attached to the cell membrane of B lymphocytes (B cells); in conjunction with helper T cells, it triggers B cell activation on contact with antigen.
beta r's (beta-adrenergic r's) adrenergic receptors that are stimulated by epinephrine and blocked by agents such as propranolol. They are subdivided into two basic types: β1-receptors are found in the myocardium and cause lipolysis and cardiac stimulation, and β2-receptors are found in smooth and skeletal muscle and liver and cause bronchodilation and vasodilation. A third type, β3, is atypical; it is more sensitive to norepinephrine than to epinephrine, relatively resistant to propranolol blockade, and may be involved in lipolysis regulation in adipose tissue. Called also β-receptors and β-adrenergic receptors.
cell-surface receptor membrane receptor.
cholinergic r's membrane receptors on cells of effector organs, innervated by cholinergic nerve fibers and responsive to the acetylcholine secreted by these fibers. There are two types, muscarinic receptors and nicotinic receptors.
complement receptor a membrane receptor that can bind activated complement components. For example, component C3b binds to complement receptors of neutrophils, B lymphocytes, and macrophages.
estrogen receptor a cellular regulatory protein that binds estrogenic hormones, found particularly in estrogen-sensitive tissues such as the uterus and breast. Cytoplasmic levels are measured in surgically removed breast carcinomas; high levels indicate that a positive response to endocrine therapy is likely.
Fc r's specific membrane receptors for antigen-antibody complexes or aggregated immunoglobulins that bind a site in the Fc portion of the immunoglobulin molecule and may exhibit specificity for particular immunoglobulin classes. Fc receptors are found on B cells, K cells, macrophages, neutrophils, and eosinophils, and, during some developmental stages, on T cells.
histamine r's receptors for histamine. H1-receptors mediate contraction of smooth muscles and dilation of capillaries, causing effects such as bronchoconstriction and contraction of the intestine; they are blocked by antihistamines such as pyrilamine or chlorpheniramine. H2-receptors mediate acceleration of the heart rate and produce gastric acid secretion; they are blocked by agents such as cimetidine.
IgE r's membrane receptors for IgE, found on mast cells and basophils.
insulin r's a type of membrane receptors specific for insulin, found on target cells.
LDL r's (low-density lipoprotein r's) specific receptors for low-density lipoproteins found in coated pits on the surface of mammalian cells. The coated pits are internalized forming coated vesicles from which the receptors are recycled back to the plasma membrane while particles of low-density lipoprotein are transferred to lysosomes where they are degraded, releasing free cholesterol, phospholipids, and amino acids. Genetic defects in LDL receptors are responsible for familial hypercholesterolemia.
membrane receptor a receptor located on or in the membrane of a cell. Called also cell-surface receptor.
muscarinic r's cholinergic receptors on autonomic effector cells (and also on some autonomic ganglion cells and in some central neurons) that are stimulated by muscarine and parasympathomimetic drugs and blocked by atropine.
nicotinic r's cholinergic receptors of autonomic ganglion cells and motor end-plates of skeletal muscle that are stimulated by low doses of nicotine and blockaded by high doses of nicotine or by tubocurarine.
olfactory receptor a specialized sensory nerve-ending sensitive to stimulation giving rise to the sensation of odors; called also osmoreceptor.
Structure of the olfactory receptors. (From Applegate, 2000.)
opiate r's (opioid r's) receptors that combine with particular opiates to create analgesia and certain other effects. Several different ones have been identified and assigned Greek letters; the μ receptor gives superior analgesia, and the κ receptor is associated with a low degree of physical dependency.
pain r's free nerve endings that are receptors for pain.
stretch receptor a sense organ in a muscle or tendon that responds to elongation.
T cell r's the characteristic marker of T lymphocytes (T cells) that recognize specific foreign antigens as well as self MHC antigens; both must be seen simultaneously to trigger T cell activation (see also lymphocyte activation). The receptor is not a complete immunoglobulin molecule but may contain heavy and light chain variable regions.

estrogen receptor (ER),

receptor for estrogens; its presence conveys a better prognosis for breast cancers.

estrogen receptor

A protein of a superfamily of nuclear receptors for small hydrophilic ligands–eg, steroid hormones, thyroid hormone, vitamin D, retinoids; the presence of ERs in breast CA generally is associated with a better prognosis, as they respond to hormonal manipulation. See Tamoxifen.  ERs are transcription factors that are regulated allosterically by binding a ligand; extracellular estradiol diffuses across the cell membrane, binds to the ER, leading to its dimerization and binding of ER to the estrogen responsive element, the ER's specific DNA target

es·tro·gen re·cep·tor

(es'trŏ-jen rĕ-sep'tŏr)
Receptor for estrogens; its presence conveys a better prognosis for breast cancers.
Synonym(s): oestrogen receptor.
References in periodicals archive ?
First-in-class drugs are those that work by a unique mechanism - in this case a molecule that targets a protein on the oestrogen receptor of tumour cells, Khaleej Times reported The potential drug offers hope for patients whose breast cancer has become resistant to traditional therapies.
Researchers at Karolinska Institute in Sweden have discovered that the risk of death from breast cancer is twice as high for patients with high heterogeneity of the oestrogen receptor within the same tumour as compared to patients with low heterogeneity.
Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues.
Breast cancer patients whose lesions contain both oestrogen receptor [ER] and progesterone receptor [PR] have the best probability of remission following hormonal therapy (Approaching 70%) than the group of patients whose lesions contain either receptor alone (Approximately 30%) or very low levels of both receptors (Approximately 10%).
Human oestrogen receptor cDNA: sequence, expression and homology to v-ERP-A.
Kim et al., "Exploiting the apoptotic actions of oestrogen to reverse antihormonal drug resistance in oestrogen receptor positive breast cancer patients," Breast, vol.
Doctors feared a baby raised chances of relapse in oestrogen receptor positive cancer but research found similar rates whether patients were pregnant or not.
In order to develop an oestrogen treatment that utilises the favourable effects of the oestrogen but not its side-effects, researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have analysed which parts of the oestrogen receptor is most important in enabling oestrogen to act on bone tissue and other tissues.
The majority of breast cancers express the oestrogen receptor and are thus potentially suitable for hormone therapy.
Association of oestrogen receptor alpha gene polymorphism with the angiographic extent of coronary artery disease.
These researchers have analysed the long-term effects of early trials where women with low-risk cancers--those who are lymph node negative, oestrogen receptor positive-were put on alternative regimens after surgery.
A G[alpha]s protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects from oestradiol on [[[Ca.sup.2+]].sub.i] in female rat distal colon.