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We suggested that the event was bilateral sterile inflammation triggered by the intravitreal injection of aflibercept and/or triamcinolone acetonide in the presence of severe rubeosis iridis due to ocular ischemic syndrome. A week after the left cataract surgery and five days after the right phacovitrectomy both anterior segments became quieter with an hourly prednisolone acetate drops and topical steroid was tapered slowly.
It is likely that underlying ocular ischemic syndrome might facilitate the formation of sterile inflammation as ocular ischemic syndrome can be associated with a bloodaqueous barrier disruption and flare.
Netto, "Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome
in the rat," Graefe's Archive for Clinical and Experimental Ophthalmology, vol.