Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan
) SPECT in patients with neuroendocrine tumours.
The somatostatin receptor-positive octreoscan
scintigraphy and bone scan revealed no metastasis.
Neuroendocrine tumor of unknown primary was defined by lack of visual evidence of primary tumor on CT scan and or Octreoscan
. Neuroendocrine tumors were histopathologically graded based on 2010 WHO classification.
Schuster et al., "Octreoscan
Versus FDG-PET for Neuroendocrine Tumor Staging: A Biological Approach," Annals of Surgical Oncology, vol.
Further investigations in hospital during his stay included free plasma normetanephrine 14.44 nmol/L (N<1.2 nmol/L) and metanephrine 6.09 nmol/L (N< 0.48 nmol/L), a negative cerebral CT scan, and an Octreoscan
showing no site of extra-adrenal uptake.
 reported that the 2 subgroups show a different positivity to [sup.18]F-fluorodeoxyglucose positron emission tomography/computerized tomography ([sup.18]F-FDG-PET/CT) or octreoscan
. In a recent study, we showed that [sup.68]Gallium([sup.68]Ga-) PET/CT was a discriminating factor for patients with G3 GEP-NECs treated with first-line platinum-based chemotherapy.
Nuclear medicine techniques (octreoscan
, gallium-68 DOTA positron emission tomography) are more specific than conventional imaging, enable whole-body imaging for staging, and may help to predict the response to peptide receptor radionuclide therapy (PRRT), if necessary at any stage of the therapeutic management .
According to recent papers, PET (positron emission tomography)/CT with [sup.68]Ga-labeled somatostatin analogues should be the examination of choice for both staging and localization in non-insulinoma PanNETs and has replaced the suboptimal octreoscan
, with a sensitivity and a specificity of 86-100% and 79-100%, respectively .
Para la deteccion de metastasis, esta descrito el uso de imagenes diagnosticas con somatostatina como marcador (OctreoScan
), que parte de la afinidad de los receptores de las celulas tumorales a dicha molecula.
In addition, positron emission tomography (PET) scan and octreoscan
are other suggested modalities .
No other primary lesion was detected on other imaging, including octreoscan
, bone scan, ultrasonography of both breasts and thyroid gland, and endoscopy including a capsule study.