obesogen

(redirected from Obesogens)

obesogen

An exogenous substance that alters lipid homeostasis and fat storage, changes metabolic setpoints, disrupts energy balance or modifies the regulation of appetite and satiety, promoting fat accumulation and obesity.

Mechanisms of action
Alteration of metabolic sensing, neuroendocrine effects, cell signalling, dysregulation of steroid hormones.

Obesogens
Pharmaceutical obesogens
• Metabolic sensors—Act on PPAR-gamma receptor (e.g., thiazolidinediones, rosiglitazone);
• Sex steroid dysregulation—DES caused obesity in adults;
• Central—Act on neurotransmitter receptors (e.g., SSRIs, antidepressants).

Environmental obesogens
• Organotin;
• Xernobiotics.
References in periodicals archive ?
However, LeBlanc says it would be premature to call this a model organism for the study of obesogens.
Adult exposure to obesogens has also been shown to trigger weight gain and other endocrine issues while exacerbating the effects of earlier exposure.
Two of three experiments they are working on have to do with obesogens, which she described as "compounds that we can get from our diet or industrial products like plastics that may predispose people to weight gain.
He and his colleagues first identified the role of obesogens in a 2006 publication and showed in 2010 that TBT acts in part by modifying the fate of mesenchymal stem cells during development, predisposing them to become fat cells.
Obesogens "trick" our bodies into thinking they are natural hormones.
One of the world's leading experts on these pollutants, dubbed obesogens said: "It is the first good study of the effects of the foetus.
MascareSas will discuss the health implications of transportation and community planning, food and environment, and focus on the emerging science and the policy debate around obesogens (chemicals linked to obesity).
The chemicals that disrupt the function of our hormonal system are called obesogens, reports CBS News.
In addition to eye-opening scientific findings on obesogens and their effect on our weight and our health, The New American Diet provides must-have information for families on how to protect themselves from obesity-causing chemicals; a complete seven-day eating plan (with recipes
Although genetics, diet, and exercise all contribute to obesity, recent studies have shown that prenatal exposures to "environmental obesogens," including bisphenol A, phthalates, organotins, and perflourinated compounds may increase the risk of obesity in children (Janesick and Blumberg 2011).
2) In this issue of EHP, a team of investigators report further evidence that components of FM550 may act as environmental obesogens, stimulating adipogenesis (fat formation) at the expense of bone health.