LEP

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LEP

A gene on chromosome 7q31.3 that encodes leptin, a protein secreted by white adipocytes, which plays a key role in regulating body weight. By binding to its cognate receptor, leptin is part of a signalling pathway which inhibits food intake and regulates energy expenditure to maintain fat homeostasis. Leptin plays a role in the endocrine system, and is involved in regulating immune and inflammatory responses, haematopoiesis, angiogenesis, reproduction, glucose homeostasis, bone formation, and wound healing.

Molecular pathology
Mutations of LEP and/or its regulatory regions are linked to obesity, morbid obesity with hypogonadism, and type-2 diabetes.
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References in periodicals archive ?
Although the relationship between obesity and PSA in prostate cancer remains controversial, previous studies have demonstrated an inverse relationship between serum PSA levels and obesity factors like BMI and WC in other populations of the world (8,19,20).
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