VAV3(redirected from OTTHUMP00000233737)
VAV3A gene on chromosome 1p13.3 that encodes a member of the VAV guanine nucleotide exchange factor (GEF) family of genes. VAV3 is GEF for the Rho family of Ras-related GTPases, and plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
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