VCAN

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VCAN

A gene on chromosome 5q14.3 that encodes an aggrecan/versican proteoglycan, which is a large chondroitin sulphate and major component of the extracellular matrix involved in cell adhesion, proliferation, migration and angiogenesis, and which plays a central role in tissue morphogenesis and maintenance.

Molecular pathology
VCAN mutations cause Wagner syndrome type 1.
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