CLCN3

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CLCN3

A gene on chromosome 4q33 that encodes a voltage-gated chloride channel that mediates exchange of chloride ions for protons, acting as as antiporter and contributing to acidification of endosomal and synaptic vesicle lumina; it thus may affect vesicle trafficking and exocytosis. CLCN3 may play a role in neuronal cell function by regulating membrane excitability by protein kinase C, and may have a role in short-term memory.