ARNT(redirected from OTTHUMP00000218220)
ARNTA gene on chromosome 1q21 that encodes aryl hydrocarbon receptor, which is involved in inducing several enzymes that participate in xenobiotic metabolism—e.g., of dioxin and polycyclic aromatic hydrocarbons—resulting in translocation of the ligand-binding subunit to the nucleus.
A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia.
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