HOXA5

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HOXA5

A gene on chromosome 7p15.2 that encodes a DNA-binding transcription factor, which provides cells with specific positional identities along the anterior-posterior axis during embryonic development and is involved in gene expression, morphogenesis and differentiation.

Molecular pathology
HOX5A methylation may result in a loss of expression of the protein product—which normally upregulates p53, the tumour suppressor—thus indirectly playing a role in cancer development.
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