SERPINE1(redirected from OTTHUMP00000211478)
SERPINE1A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.