HCN4

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HCN4

A gene on chromosome 15q24.1 that encodes a member of the hyperpolarisation-activated cyclic nucleotide-gated potassium channels, which has slow activation and inactivation kinetics, and is critical in cardiac pacemaking. HCN4 may mediate responses to sour taste stimuli.

Molecular pathology
HCN4 mutations are linked to sick sinus syndrome 2—e.g., atrial fibrillation with bradyarrhythmia or familial sinus bradycardia.
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