ITGB6(redirected from OTTHUMP00000162896)
ITGB6A gene on chromosome 2q24.2 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-6 chain partners with the alpha-5 chain to form a receptor for fibronectin and cytotactin, which recognises the RGD sequence in the ligands.
Clathrin-mediated endocytosis of integrin alpha-5/beta-6 promotes carcinoma invasion.
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