SPINK1(redirected from OTTHUMP00000160145)
SPINK1A gene on chromosome 5q32 that encodes a trypsin inhibitor secreted from pancreatic acinar cells into pancreatic juice. SPINK1 is thought to prevent trypsin-catalysed premature activation of zymogens within the pancreas and the pancreatic duct.
SPINK1 mutations are associated with hereditary pancreatitis and tropical calcific pancreatitis.
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