RCC1(redirected from OTTHUMP00000003777)
RCC1A gene on chromosome 1p36.1 that encodes a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. The RCC1 protein product helps regulate the onset of S-phase chromosome condensation, binding to nucleosomes and double-stranded DNA. The RCC1-Ran complex with other proteins is part of a signal transmission pathway that detects unreplicated DNA. RCC1 plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
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