RUNX2

(redirected from OSF2)
Also found in: Acronyms.

RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
References in periodicals archive ?
Although Jago (1971) regards the 3 as subgenera of Stenobothrus, the OSF2, curiously, assigns them to different tribes: Myrmeleotettix to tribe Gomphocerini and the other 2 to tribe Stenobothrini.
Stenohippus and Thyridota have not yet been assigned to tribe by the OSF2. The remaining three genera belong to different tribes.
The genus Ochrilidia is centered in Africa, but some species also occur in southern Europe and south-west Asia including India (BeiBienko & Mishchenko 1951, Dirsch 1965, OSF2).
Although Eutryxalis and Covasacris have not been assigned to tribe by OSF2, Donato (2003a, 2003b) placed them in the tribe Hyalopterygini along with Metaleptea and Parorphula (some species of which have been synonymized with C.