RUNX2

(redirected from OSF2)
Also found in: Acronyms.

RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
References in periodicals archive ?
Stenohippus and Thyridota have not yet been assigned to tribe by the OSF2.
Although Eutryxalis and Covasacris have not been assigned to tribe by OSF2, Donato (2003a, 2003b) placed them in the tribe Hyalopterygini along with Metaleptea and Parorphula (some species of which have been synonymized with C.
Morphacris has not yet been assigned to tribe according to the OSF2, although Petit et al.