ARID1A

(redirected from OSA1)

ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in periodicals archive ?
Starting with clinical case reports of severe OSA (19, 20), going to RCT with moderate OSA1, to mild or moderate OSA (3, 17) to RCT (2, 4) with all three levels of OSA severity.
OSA1 is used to record the output signal and OSA2 used to record the Brillouin Stocks power.
In the single-pass RFA (configuration A), the input signal is injected to the RFA architecture via port 1 of the optical circulator prior to propagate over the gain medium, and the output signal power record by OSA1 via signal port of the wavelength division multiplexer (WDM).
There is an optical spectrum analyzer (OSA1) connected at the output of WDM for calculating and displaying optical signals.