OS9


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OS9

A gene on chromosome 12q13 that encodes a ubiquitous lectin which binds selectively to improperly folded luminal proteins. OS9 plays a role in endoplasmic reticulum (ER) quality control and ER-associated degradation of misfolded proteins and retaining them in the ER, possibly transferring them to the ubiquitination machinery and promoting their degradation.
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References in periodicals archive ?
To evaluate meprin degradation of OS9 in vivo, cytosolic-enriched kidney protein fractions from WT and meprin [alpha][beta]KO mice subjected to IR were evaluated for fragmentation using Western blot.
Western blot analysis was used to confirm meprin B protein expression by the transfected MDCK cells, to evaluate the levels of HiF-1& and OS9 in kidney proteins and MDCK protein lysates, and for evaluating fragmentation and/or degradation of OS-9.