ORAI3

ORAI3

A gene on chromosome 16p11.2 that encodes a Ca2+ release-activated Ca2+ (CRAC) channel subunit, which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T cells and promote an immune response to pathogens by activating the transcription factor NFAT. It is a key regulator of store-operated Ca(2+) channel.
References in periodicals archive ?
Studying the calcium channels known as ORAI1, ORAI2 and ORAI3 and their regulators STIM1 and STIM2 helps us to define ways to modulate immune responses for therapeutic use."