ORAI2

ORAI2

A gene on chromosome 7q22.1 that encodes a Ca2+ release-activated Ca2+ (CRAC) channel subunit, which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T cells and promote an immune response to pathogens by activating the transcription factor NFAT.
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References in periodicals archive ?
Studying the calcium channels known as ORAI1, ORAI2 and ORAI3 and their regulators STIM1 and STIM2 helps us to define ways to modulate immune responses for therapeutic use."
To assess the expression levels of the different [Ca.sup.2+] channels and transporters in human VSM cells, we used real-time PCR to evaluate mRNA levels of PMCA1, PMCA4, Orail, Orai2, stim1, STIM2, and SERCA1-3.
Song et al., "Upregulated expression of STIM2, TRPC6, and orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype," American Journal of Physiology--Cell Physiology, vol.