ORAI1

ORAI1

A gene on chromosome 12q24.31 that encodes a Ca2+ release-activated Ca2+ (CRAC) channel subunit, which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T cells and promote an immune response to pathogens by activating the transcription factor NFAT.

Molecular pathology
Defects in ORAI1 cause immune dysfunction with T-cell inactivation due to calcium entry defect type 1.
References in periodicals archive ?
The paper, titled "Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models" appears in the August edition of the journal Gastroenterology.
Hogan said that they are not sure why, but theorized that septins rearrange the cellular membrane's structure to "corral" the key proteins STIM and ORAI1, and maybe other factors needed for the calcium channel to operate.
Dominant-negative isoforms of STIM1 and ORAI1, -2 and -3 were provided by L.
The researchers conducted their studies in mice because patients with mutations in the STIM1 gene and that of the channel it activates, ORAI1, are extremely rare and often too sick to study due to chronic infections and lymphoproliferative disease.